Prion protein interacts with the metabotropic glutamate receptor 1 and regulates the organization of Ca

Animals Calcium / metabolism Calcium Signaling Cell Line Mice Neurons / metabolism Prion Proteins / metabolism Protein Interaction Maps Receptors, Metabotropic Glutamate / metabolism
Ca(2+) Cellular prion protein Prion diseases mGluR1

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
30 04 2020
Historique:
received: 03 02 2020
accepted: 15 02 2020
pubmed: 29 2 2020
medline: 12 11 2020
entrez: 29 2 2020
Statut: ppublish

Résumé

Cellular prion protein (PrP) is a membrane protein that is highly conserved among mammals and mainly expressed on the cell surface of neurons. Despite its reported interactions with various membrane proteins, no functional studies have so far been carried out on it, and its physiological functions remain unclear. Neuronal cell death has been observed in a PrP-knockout mouse model expressing Doppel protein, suggesting that PrP might be involved in Ca

Identifiants

DOI: 10.1016/j.bbrc.2020.02.102 PMID: 32107004
pubmed: 32107004
pii: S0006-291X(20)30376-4
doi: 10.1016/j.bbrc.2020.02.102
pii:
doi:

Substances chimiques

Prion Proteins 0
Receptors, Metabotropic Glutamate 0
metabotropic glutamate receptor type 1 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

447-454

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Takehiro Matsubara (T)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan; Okayama University Hospital Biobank, Okayama University Hospital, Okayama, Japan.

Katsuya Satoh (K)

Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Takujiro Homma (T)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Japan.

Takehiro Nakagaki (T)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Naohiro Yamaguchi (N)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Ryuichiro Atarashi (R)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan; Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Japan.

Yuka Sudo (Y)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan; Cancer Pathophysiology Division, National Cancer Center, Research Institute, Japan.

Yasuhito Uezono (Y)

Cancer Pathophysiology Division, National Cancer Center, Research Institute, Japan.

Daisuke Ishibashi (D)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan. Electronic address: dishi@nagasaki-u.ac.jp.

Noriyuki Nishida (N)

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Japan.

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Classifications MeSH

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