Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life.
Allergens
/ immunology
Arachis
/ immunology
B-Lymphocytes
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Dendritic Cells
/ immunology
Female
Humans
Immune Tolerance
/ immunology
Immunoglobulin E
/ immunology
Immunologic Memory
Infant
Male
Mass Spectrometry
/ methods
Peanut Hypersensitivity
/ diagnosis
Primary Cell Culture
Tumor Necrosis Factor-alpha
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 02 2020
27 02 2020
Historique:
received:
04
10
2019
accepted:
11
02
2020
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
6
5
2020
Statut:
epublish
Résumé
IgE-mediated peanut allergic is common, often serious, and usually lifelong. Not all individuals who produce peanut-specific IgE will react upon consumption of peanut and can eat the food without adverse reactions, known as sensitized tolerance. Here, we employ high-dimensional mass cytometry to define the circulating immune cell signatures associated with sensitized tolerance and clinical allergy to peanut in the first year of life. Key features of clinical peanut allergic are increased frequency of activated B cells (CD19
Identifiants
pubmed: 32107388
doi: 10.1038/s41467-020-14919-4
pii: 10.1038/s41467-020-14919-4
pmc: PMC7046671
doi:
Substances chimiques
Allergens
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1091Subventions
Organisme : NIAID NIH HHS
ID : R01 AI140134
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI140498
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI104209
Pays : United States
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