Plantaricin NC8 αβ exerts potent antimicrobial activity against Staphylococcus spp. and enhances the effects of antibiotics.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
27 02 2020
Historique:
received: 12 09 2019
accepted: 13 02 2020
entrez: 29 2 2020
pubmed: 29 2 2020
medline: 15 12 2020
Statut: epublish

Résumé

The use of conventional antibiotics has substantial clinical efficacy, however these vital antimicrobial agents are becoming less effective due to the dramatic increase in antibiotic-resistant bacteria. Novel approaches to combat bacterial infections are urgently needed and bacteriocins represent a promising alternative. In this study, the activities of the two-peptide bacteriocin PLNC8 αβ were investigated against different Staphylococcus spp. The peptide sequences of PLNC8 α and β were modified, either through truncation or replacement of all L-amino acids with D-amino acids. Both L- and D-PLNC8 αβ caused rapid disruption of lipid membrane integrity and were effective against both susceptible and antibiotic resistant strains. The D-enantiomer was stable against proteolytic degradation by trypsin compared to the L-enantiomer. Of the truncated peptides, β1-22, β7-34 and β1-20 retained an inhibitory activity. The peptides diffused rapidly (2 min) through the bacterial cell wall and permeabilized the cell membrane, causing swelling with a disorganized peptidoglycan layer. Interestingly, sub-MIC concentrations of PLNC8 αβ substantially enhanced the effects of different antibiotics in an additive or synergistic manner. This study shows that PLNC8 αβ is active against Staphylococcus spp. and may be developed as adjuvant in combination therapy to potentiate the effects of antibiotics and reduce their overall use.

Identifiants

pubmed: 32107445
doi: 10.1038/s41598-020-60570-w
pii: 10.1038/s41598-020-60570-w
pmc: PMC7046733
doi:

Substances chimiques

Anti-Bacterial Agents 0
Bacteriocins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3580

Commentaires et corrections

Type : ErratumIn

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Auteurs

Torbjörn Bengtsson (T)

Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Örebro, SE-70362, Sweden.

Robert Selegård (R)

Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Örebro, SE-70362, Sweden.
Division of Molecular Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, SE-58183, Sweden.

Amani Musa (A)

Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Örebro, SE-70362, Sweden.

Kjell Hultenby (K)

Department of Laboratory Medicine, Division of Clinical Research Centre, Karolinska Institutet, Stockholm, SE-14186, Sweden.

Johanna Utterström (J)

Division of Molecular Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, SE-58183, Sweden.

Petter Sivlér (P)

S2Medical AB, Linköping, SE-58273, Sweden.

Mårten Skog (M)

S2Medical AB, Linköping, SE-58273, Sweden.

Fariba Nayeri (F)

PEAS Research Institute, Department of Infection Control, Linköping, SE-58273, Sweden.

Bengt Hellmark (B)

Department of Clinical Microbiology, Örebro University Hospital, Örebro, SE-70185, Sweden.

Bo Söderquist (B)

Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Örebro, SE-70362, Sweden.
Department of Clinical Microbiology, Örebro University Hospital, Örebro, SE-70185, Sweden.

Daniel Aili (D)

Division of Molecular Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, SE-58183, Sweden.

Hazem Khalaf (H)

Cardiovascular Research Centre, School of Medical Sciences, Örebro University, Örebro, SE-70362, Sweden. hazem.khalaf@oru.se.

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