Methylation of the LEP gene promoter in blood at 12 months and BMI at 4 years of age-a population-based cohort study.
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
23
07
2019
accepted:
12
02
2020
revised:
06
02
2020
pubmed:
29
2
2020
medline:
3
8
2021
entrez:
29
2
2020
Statut:
ppublish
Résumé
Increasing evidence links epigenetic variation to anthropometric and metabolic measures. Leptin signalling regulates appetite and energy expenditure, and in pregnancy is important for nutrient supply to the foetus. Maternal metabolic health and foetal growth are linked to infant blood leptin gene (LEP) methylation, which has been cross-sectionally associated with adolescent obesity. Despite this, few studies have explored the relationship between infant LEP methylation and childhood anthropometry, or the impact of genetic variation on these relationships. Using a prospective birth cohort, we investigated whether blood LEP promoter methylation at birth and 12 months predicts weight and adiposity at 4-years. Locus-specific methylation data was analysed by partial correlation tests and multivariable linear regression. There was weak evidence of an association of birth LEP methylation with anthropometry measures at 4 years. Methylation at a specific site (cg19594666) at 12 months was inversely associated with 4-year weight (r = -0.11, p = 0.02) and body-mass index (BMI) (r = -0.13, p = 0.007), which persisted following adjustment for weight at birth and at 12 months. Neither association was influenced by genotype. We report the first evidence of an association between LEP methylation in infancy and childhood weight. Replication in additional cohorts is required to determine if this relationship persists.
Identifiants
pubmed: 32107462
doi: 10.1038/s41366-020-0553-3
pii: 10.1038/s41366-020-0553-3
doi:
Substances chimiques
LEP protein, human
0
Leptin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
842-847Investigateurs
Peter Vuillermin
(P)
Fiona Collier
(F)
Anne-Louise Ponsonby
(AL)
John Carlin
(J)
Katie Allen
(K)
Mimi Tang
(M)
Richard Saffery
(R)
Sarath Ranganathan
(S)
David Burgner
(D)
Terry Dwyer
(T)
Peter Sly
(P)
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