Botulinum Toxin as a Biological Warfare Agent: Poisoning, Diagnosis and Countermeasures.
Acetylcholine
Clostridium botulinum
antiserum
biological warfare agent
botulinum toxin
botulism
detection
diagnosis
poisoning.
Journal
Mini reviews in medicinal chemistry
ISSN: 1875-5607
Titre abrégé: Mini Rev Med Chem
Pays: Netherlands
ID NLM: 101094212
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
09
2019
revised:
06
02
2020
accepted:
13
02
2020
pubmed:
29
2
2020
medline:
1
1
2021
entrez:
29
2
2020
Statut:
ppublish
Résumé
Botulinum toxin is a neurotoxin produced by Clostridium botulinum and some other relative species. It causes a lethal disease called botulism. It can enter the body via infections by Clostridium (e.g. wound and children botulism) or by direct contact with the toxin or eating contaminated food (food-borne botulism). Botulinum toxin is also considered as a relevant biological warfare agent with an expected high number of causalities when misused for bioterrorist or military purposes. The current paper surveys the actual knowledge about botulinum toxin pathogenesis, the manifestation of poisoning, and current trends in diagnostics and therapeutics. Relevant and recent literature is summarized in this paper.
Identifiants
pubmed: 32108007
pii: MRMC-EPUB-104901
doi: 10.2174/1389557520666200228105312
doi:
Substances chimiques
Biological Warfare Agents
0
Botulinum Toxins
EC 3.4.24.69
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
865-874Informations de copyright
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