Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Amino Acid Sequence
Betacoronavirus
/ genetics
Binding Sites
COVID-19
COVID-19 Vaccines
Computational Biology
/ methods
Coronavirus Infections
/ immunology
Epitopes
/ chemistry
Epitopes, B-Lymphocyte
/ chemistry
Epitopes, T-Lymphocyte
/ chemistry
Histocompatibility Antigens Class I
/ chemistry
Histocompatibility Antigens Class II
/ chemistry
Humans
Middle East Respiratory Syndrome Coronavirus
/ genetics
Molecular Docking Simulation
Pandemics
/ prevention & control
Pneumonia, Viral
/ immunology
Protein Binding
Protein Interaction Domains and Motifs
Protein Structure, Tertiary
Severe acute respiratory syndrome-related coronavirus
/ genetics
SARS-CoV-2
Spike Glycoprotein, Coronavirus
/ chemistry
Toll-Like Receptor 5
/ chemistry
Vaccines, Subunit
Viral Vaccines
/ chemistry
SARS-COV-2
epitopes
immunoinformatics
vaccine
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
22
02
2020
accepted:
26
02
2020
pubmed:
29
2
2020
medline:
1
7
2020
entrez:
29
2
2020
Statut:
ppublish
Résumé
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
Identifiants
pubmed: 32108359
doi: 10.1002/jmv.25736
pmc: PMC7228377
doi:
Substances chimiques
COVID-19 Vaccines
0
Epitopes
0
Epitopes, B-Lymphocyte
0
Epitopes, T-Lymphocyte
0
Histocompatibility Antigens Class I
0
Histocompatibility Antigens Class II
0
Spike Glycoprotein, Coronavirus
0
TLR5 protein, human
0
Toll-Like Receptor 5
0
Vaccines, Subunit
0
Viral Vaccines
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
618-631Subventions
Organisme : Hallym University Research Fund
Pays : International
Organisme : National Research Foundation of Korea (NRF)
ID : NRF-2017R1A2B4012944
Pays : International
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals, Inc.
Références
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Bioinformatics. 2001 Dec;17(12):1236-7
pubmed: 11751237
Nucleic Acids Res. 2012 Jul;40(Web Server issue):W525-30
pubmed: 22610854
Nucleic Acids Res. 2016 Jan 4;44(D1):D7-19
pubmed: 26615191
BMC Bioinformatics. 2007 Jan 05;8:4
pubmed: 17207271
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W407-10
pubmed: 17517781
Am J Respir Crit Care Med. 2020 Feb 15;201(4):P7-P8
pubmed: 32004066
J Med Virol. 2020 Jun;92(6):618-631
pubmed: 32108359
Proteins. 2013 Dec;81(12):2096-105
pubmed: 24123488
BMC Infect Dis. 2016 May 21;16:219
pubmed: 27206475
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Radiology. 2020 Apr;295(1):202-207
pubmed: 32017661
Lancet. 2020 Feb 15;395(10223):470-473
pubmed: 31986257
JAMA. 2020 Feb 25;323(8):709-710
pubmed: 31999307
N Engl J Med. 2020 Feb 20;382(8):760-762
pubmed: 31978944
Interdiscip Sci. 2009 Dec;1(4):290-7
pubmed: 20640807
Adv Drug Deliv Rev. 2013 Oct;65(10):1357-69
pubmed: 23026637
Nucleic Acids Res. 2017 Jul 3;45(W1):W24-W29
pubmed: 28472356
Bioinformatics. 2003 May 22;19(8):1009-14
pubmed: 12761064
J Mol Model. 2011 Jul;17(7):1679-93
pubmed: 21042822
Int J Infect Dis. 2020 Feb;91:264-266
pubmed: 31953166
Bioinformatics. 2011 Aug 1;27(15):2076-82
pubmed: 21666270
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W363-7
pubmed: 15980490