Platelet depletion limits the severity but does not prevent the occurrence of experimental transfusion-related acute lung injury.
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
24
09
2019
revised:
07
02
2020
accepted:
07
02
2020
pubmed:
29
2
2020
medline:
9
9
2020
entrez:
29
2
2020
Statut:
ppublish
Résumé
Transfusion-related acute lung injury (TRALI) is a severe pulmonary reaction due to blood transfusions. The pathophysiology of this complication is still not widely elucidated by the scientific community, especially regarding the direct role of blood platelets within the cellular mechanism responsible for the development of TRALI. In this study, a mouse model was used to induce the development of antibody-mediated acute lung injury through injections of lipopolysaccharide and an anti-major histocompatibility complex Class I antibody. BALB/c mice were pretreated with an anti-GPIbα antibody, which induces platelet depletion, or ML354, a protease receptor 4 pathway inhibitor, 30 minutes before TRALI induction. Depletion of platelets before TRALI induction appeared to reduce the severity of TRALI without completely inhibiting its development. Also, inhibition of platelet activation by ML354 did not prevent the onset of TRALI. Finally, the stimuli used for TRALI induction also triggered specific platelet activation upon ex vivo stimulation. This study suggests that blood platelets are not critically required for TRALI induction, although they are to some extent involved in its pathophysiology.
Sections du résumé
BACKGROUND
Transfusion-related acute lung injury (TRALI) is a severe pulmonary reaction due to blood transfusions. The pathophysiology of this complication is still not widely elucidated by the scientific community, especially regarding the direct role of blood platelets within the cellular mechanism responsible for the development of TRALI.
STUDY DESIGN AND METHODS
In this study, a mouse model was used to induce the development of antibody-mediated acute lung injury through injections of lipopolysaccharide and an anti-major histocompatibility complex Class I antibody. BALB/c mice were pretreated with an anti-GPIbα antibody, which induces platelet depletion, or ML354, a protease receptor 4 pathway inhibitor, 30 minutes before TRALI induction.
RESULTS
Depletion of platelets before TRALI induction appeared to reduce the severity of TRALI without completely inhibiting its development. Also, inhibition of platelet activation by ML354 did not prevent the onset of TRALI. Finally, the stimuli used for TRALI induction also triggered specific platelet activation upon ex vivo stimulation.
CONCLUSIONS
This study suggests that blood platelets are not critically required for TRALI induction, although they are to some extent involved in its pathophysiology.
Substances chimiques
Antibodies
0
Indoles
0
Platelet Glycoprotein GPIb-IX Complex
0
VU0099704
0
adhesion receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
713-723Subventions
Organisme : Association "Les Amis de Rémi" Savigneux, France
ID : Grant
Pays : International
Organisme : French National Blood Service
ID : EFS (Grant APR)
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 AABB.
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