Genome-wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders.
GWAS
autism
dyslexia
genetics
neurodevelopment
reading disabilities
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
22
02
2019
revised:
28
01
2020
accepted:
24
02
2020
pubmed:
29
2
2020
medline:
17
7
2021
entrez:
29
2
2020
Statut:
ppublish
Résumé
Reading disabilities (RD) are the most common neurocognitive disorder, affecting 5% to 17% of children in North America. These children often have comorbid neurodevelopmental/psychiatric disorders, such as attention deficit/hyperactivity disorder (ADHD). The genetics of RD and their overlap with other disorders is incompletely understood. To contribute to this, we performed a genome-wide association study (GWAS) for word reading. Then, using summary statistics from neurodevelopmental/psychiatric disorders, we computed polygenic risk scores (PRS) and used them to predict reading ability in our samples. This enabled us to test the shared aetiology between RD and other disorders. The GWAS consisted of 5.3 million single nucleotide polymorphisms (SNPs) and two samples; a family-based sample recruited for reading difficulties in Toronto (n = 624) and a population-based sample recruited in Philadelphia [Philadelphia Neurodevelopmental Cohort (PNC)] (n = 4430). The Toronto sample SNP-based analysis identified suggestive SNPs (P ~ 5 × 10
Substances chimiques
CCNT1 protein, human
0
Cyclin T
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12648Subventions
Organisme : CIHR
ID : MOP-133440
Pays : Canada
Informations de copyright
© 2020 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
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