Intestinal inflammation induced by dextran sodium sulphate causes liver inflammation and lipid metabolism disfunction in laying hens.
dextran sodium sulphate
egg production
egg yolk precursor
intestinal inflammation
liver inflammation
Journal
Poultry science
ISSN: 1525-3171
Titre abrégé: Poult Sci
Pays: England
ID NLM: 0401150
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
19
08
2019
revised:
07
11
2019
accepted:
07
11
2019
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
28
8
2020
Statut:
ppublish
Résumé
Gut inflammation caused by various factors including microbial infection leads to disorder of absorption of dietary nutrients and decrease in egg production in laying hens. We hypothesized that intestinal inflammation may affect egg production in laying hens through its impact on liver function. Dextran sodium sulphate (DSS) is known to induce intestinal inflammation in mammals, but whether it also induces inflammation in laying hens is not known. The goal of this study was to assess whether oral administration of DSS is a useful model of intestinal inflammation in laying hens and to characterize the effects of intestinal inflammation on egg production using this model. White Leghorn hens (350-day old) were administrated with or without 0.9 g of DSS/kg BW in drinking water for 5 D (n = 8, each). All laid eggs were collected, and their whole and eggshell weights were recorded. Blood was collected every day and used for biochemical analysis. Liver and intestinal tissues (duodenum, jejunum, ileum, cecum, cecal-tonsil, and colon) were collected 1 D after the final treatment. These tissue samples were used for histological analysis and PCR analysis. Oral administration of DSS in laying hens caused 1) histological disintegration of the cecal mucosal epithelium and increased monocyte/macrophage infiltration and IL-1β, IL-6, CXCLi2, IL-10, and TGFβ-4 gene expression; 2) decreased egg production; 3) increased leukocyte infiltration and IL-1β, CXCLi2, and IL-10 expression in association with a high frequency of lipopolysaccharide-positive cells in the liver; and 4) decreased expression of genes related to lipid synthesis, lipoprotein uptake, and yolk precursor production. These results suggested that oral administration of DSS is a useful method for inducing intestinal inflammation in laying hens, and intestinal inflammation may reduce egg production by disrupting egg yolk precursor production in association with liver inflammation.
Identifiants
pubmed: 32111331
pii: S0032-5791(19)57825-7
doi: 10.1016/j.psj.2019.11.028
pmc: PMC7587789
pii:
doi:
Substances chimiques
Dextran Sulfate
9042-14-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1663-1677Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
Références
Clin Exp Med. 2015 Feb;15(1):107-20
pubmed: 24414342
J Nutr Biochem. 2010 Jun;21(6):468-75
pubmed: 19428234
Int J Biol Macromol. 2018 Feb;107(Pt B):2201-2210
pubmed: 29074081
Dev Comp Immunol. 2017 Jul;72:30-36
pubmed: 28223253
Gastroenterology. 1996 Apr;110(4):975-84
pubmed: 8613031
J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1045-56
pubmed: 23873964
Poult Sci. 2016 Jul 1;95(7):1529-1542
pubmed: 26976905
Poult Sci. 2015 May;94(5):906-11
pubmed: 25743415
PLoS One. 2012;7(3):e32084
pubmed: 22427817
Perspect Biol Med. 1993 Summer;36(4):611-22
pubmed: 8361844
Genet Sel Evol. 2000 Sep-Oct;32(5):521-31
pubmed: 14736380
Poult Sci. 2018 Jul 1;97(7):2287-2294
pubmed: 29660058
J Nutr. 1999 Feb;129(2S Suppl):467S-472S
pubmed: 10064311
Stem Cell Res Ther. 2015 Apr 16;6:79
pubmed: 25890182
Theriogenology. 2014 Aug;82(3):517-24
pubmed: 24938798
Blood. 2009 Mar 5;113(10):2324-35
pubmed: 19104081
Poult Sci. 2014 Nov;93(11):2772-8
pubmed: 25214558
Poult Sci. 2012 Jul;91(7):1590-7
pubmed: 22700503
J Med Microbiol. 2013 Feb;62(Pt 2):287-296
pubmed: 23161764
Gen Comp Endocrinol. 1987 Mar;65(3):331-6
pubmed: 3557097
Gut. 2014 Feb;63(2):310-6
pubmed: 23408349
Nat Protoc. 2007;2(3):541-6
pubmed: 17406617
PLoS One. 2011;6(9):e25058
pubmed: 21949848
Sci China Life Sci. 2018 Dec;61(12):1537-1544
pubmed: 29270794
Br Poult Sci. 2007 Oct;48(5):525-37
pubmed: 17952723
Eur J Cancer. 2005 Nov;41(16):2502-12
pubmed: 16199153
Lipids. 2013 Jan;48(1):13-21
pubmed: 23179392
Clin Sci (Lond). 2015 Oct;129(7):515-27
pubmed: 25948052
Microbes Infect. 1999 Dec;1(15):1367-80
pubmed: 10611763
Theriogenology. 2014 May;81(8):1129-38
pubmed: 24612789
Br Poult Sci. 2016 Dec;57(6):842-847
pubmed: 27385085
J Reprod Fertil. 1983 Sep;69(1):221-7
pubmed: 6887137
Poult Sci. 2016 Nov 1;95(11):2565-2569
pubmed: 27208154
J Biol Chem. 2011 Mar 25;286(12):10847-55
pubmed: 21282107
J Biol Chem. 2008 Jun 13;283(24):16408-15
pubmed: 18417470
Gastroenterology. 1990 Mar;98(3):694-702
pubmed: 1688816
Inflamm Bowel Dis. 2012 Feb;18(2):344-8
pubmed: 21618356
Nat Rev Immunol. 2011 Jan;11(1):9-20
pubmed: 21151034
J Poult Sci. 2018;55(2):142-149
pubmed: 32055167
Poult Sci. 2019 Jan 1;98(1):188-198
pubmed: 30239962
BMC Vet Res. 2013 Dec 17;9:257
pubmed: 24345215
J Biomed Biotechnol. 2012;2012:718617
pubmed: 22665990
J Nutr. 1997 May;127(5 Suppl):801S-804S
pubmed: 9164240
Immunogenetics. 1999 Jul;49(7-8):673-84
pubmed: 10369926
Biochem Biophys Rep. 2017 Aug 22;12:29-39
pubmed: 28955789
Oncol Rep. 2006 Dec;16(6):1357-62
pubmed: 17089061
Biochem Pharmacol. 2012 Dec 1;84(11):1459-69
pubmed: 23000912
Liver Int. 2009 Oct;29(9):1316-25
pubmed: 19558576
J Biol Chem. 2016 May 27;291(22):11504-17
pubmed: 27022031
Anim Reprod Sci. 2006 Oct;95(3-4):283-94
pubmed: 16253445
J Virol. 1993 Jun;67(6):3528-33
pubmed: 8388511
Poult Sci. 2015 Jun;94(6):1220-6
pubmed: 25877409
Avian Pathol. 2005 Jun;34(3):159-80
pubmed: 16191699
J Reprod Dev. 2011 Apr;57(2):212-6
pubmed: 21123962
Biochem J. 1952 Apr;51(1):129-33
pubmed: 14944544
Vet Immunol Immunopathol. 2006 Dec 15;114(3-4):209-23
pubmed: 16996141