Supercritical fluid technology for the development of innovative ophthalmic medical devices: Drug loaded intraocular lenses to mitigate posterior capsule opacification.
Acrylic Resins
/ chemistry
Capsule Opacification
/ prevention & control
Delayed-Action Preparations
Drug Delivery Systems
Drug Liberation
Epithelial-Mesenchymal Transition
/ drug effects
Humans
Lenses, Intraocular
Methotrexate
/ administration & dosage
Solvents
/ chemistry
Technology, Pharmaceutical
Time Factors
Capsular bag model
Drug release system
Loaded intraocular lenses
Medical devices
Methotrexate
Posterior capsule opacification
Supercritical carbon dioxide impregnation
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
20
12
2019
revised:
17
02
2020
accepted:
24
02
2020
pubmed:
1
3
2020
medline:
1
12
2020
entrez:
1
3
2020
Statut:
ppublish
Résumé
Supercritical impregnation technology was applied to load acrylic intraocular lenses (IOLs) with methotrexate to produce a sustained drug delivery device to mitigate posterior capsule opacification. Drug release kinetics were studied in vitro and used to determine the drug loading. Loaded IOLs and control IOLs treated under the same operating conditions, but without drug, were implanted ex vivo in human donor capsular bags. The typical cell growth was observed and immunofluorescence staining of three common fibrosis markers, fibronectin, F-actin and α-smooth muscle actin was carried out. Transparent IOLs presenting a sustained release of methotrexate for more than 80 days were produced. Drug loading varying between 0.43 and 0.75 ± 0.03 µg
Identifiants
pubmed: 32112896
pii: S0939-6411(20)30052-7
doi: 10.1016/j.ejpb.2020.02.011
pii:
doi:
Substances chimiques
Acrylic Resins
0
Delayed-Action Preparations
0
Solvents
0
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
248-256Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.