Charting the Fragmented Landscape of Drug Synergy.

Drug Synergism Drug Therapy, Combination Humans
Bliss Independence Loewe Additivity drug synergy

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
04 2020
Historique:
received: 25 10 2019
revised: 16 01 2020
accepted: 29 01 2020
pubmed: 3 3 2020
medline: 16 4 2021
entrez: 2 3 2020
Statut: ppublish

Résumé

Even as the clinical impact of drug combinations continues to accelerate, no consensus on how to quantify drug synergy has emerged. Rather, surveying the landscape of drug synergy reveals the persistence of historical fissures regarding the appropriate domains of conflicting synergy models - fissures impacting all aspects of combination therapy discovery and deployment. Herein we chronicle the impact of these divisions on: (i) the design, interpretation, and reproducibility of high-throughput combination screens; (ii) the performance of algorithms to predict synergistic mixtures; and (iii) the search for higher-order synergistic interactions. Further progress in each of these subfields hinges on reaching a consensus regarding the long-standing rifts in the field.

Identifiants

DOI: 10.1016/j.tips.2020.01.011 PMID: 32113653 PMC: PMC7986484
pubmed: 32113653
pii: S0165-6147(20)30025-0
doi: 10.1016/j.tips.2020.01.011
pmc: PMC7986484
mid: NIHMS1567441
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

266-280

Subventions

Organisme : NCI NIH HHS
ID : R01 CA186193
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK101003
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA215845
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA217450
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Christian T Meyer (CT)

Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA.

David J Wooten (DJ)

Department of Physics, Pennsylvania State University, University Park, PA, USA.

Carlos F Lopez (CF)

Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.

Vito Quaranta (V)

Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA; Department of Biochemistry, Vanderbilt University, Nashville, TN, USA. Electronic address: vito.quaranta@vanderbilt.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Synergie des médicaments › Charting the Fragmented Landscape of Drug Synergy.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Charting the Fragmented Landscape of Drug Synergy.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Charting the Fragmented Landscape of Drug Synergy.