Prognosis and Reclassification by YKL-40 in Stable Coronary Artery Disease.
Aged
Anti-Bacterial Agents
/ therapeutic use
Biomarkers
/ blood
C-Reactive Protein
/ metabolism
Chitinase-3-Like Protein 1
/ blood
Clarithromycin
/ therapeutic use
Coronary Artery Disease
/ blood
Female
Follow-Up Studies
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Survival Rate
CHI3L1
YKL‐40
cohort study
coronary atherosclerosis
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
18
3
2021
Statut:
ppublish
Résumé
Background The inflammatory biomarker YKL-40 has previously been studied as a potential risk marker in cardiovascular disease. We aimed to assess the prognostic reclassification potential of serum YKL-40 in patients with stable coronary artery disease. Methods and Results The main study population was the placebo group of the CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) trial. The primary outcome was a composite of acute myocardial infarction, unstable angina pectoris, cerebrovascular disease, and all-cause mortality. We used Cox proportional hazards regression models adjusted for C-reactive protein level and baseline cardiovascular risk factors. Improvement in prediction by adding serum YKL-40 to the risk factors was calculated using the Cox-Breslow method and c-statistic. A total of 2200 patients were randomized to placebo, with a follow-up duration of 10 years. YKL-40 was associated with an increased risk of the composite outcome (hazard ratio per unit increase in (YKL-40) 1.13, 95% CI 1.03-1.24,
Identifiants
pubmed: 32114892
doi: 10.1161/JAHA.119.014634
pmc: PMC7335588
doi:
Substances chimiques
Anti-Bacterial Agents
0
Biomarkers
0
CHI3L1 protein, human
0
Chitinase-3-Like Protein 1
0
C-Reactive Protein
9007-41-4
Clarithromycin
H1250JIK0A
Banques de données
ClinicalTrials.gov
['NCT00121550']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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