Unpredictable maternal behavior is associated with a blunted infant cortisol response.
HPA axis
infant
parental care
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
16
09
2019
revised:
03
02
2020
accepted:
09
02
2020
pubmed:
3
3
2020
medline:
29
6
2021
entrez:
3
3
2020
Statut:
ppublish
Résumé
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with poor physical and mental health. Early-life adversity may dysregulate cortisol response to subsequent stress. This study examines the association between patterns of maternal behavior and infant stress response to a challenge. Specifically, we test whether infant exposure to unpredictable maternal sensory signals is related to the cortisol response to a painful stressor. Participants were 102 mothers and their children enrolled in a longitudinal study. Patterns of maternal sensory signals were evaluated at 6 and 12 months during a 10-min mother-infant play episode. Entropy rate was calculated as a quantitative measure of the degree of unpredictability of maternal sensory signals (visual, auditory, and tactile) exhibited during the play episode. Infant saliva samples were collected for cortisol analysis before and after inoculation at 12 months. Unpredictable patterns of maternal sensory signals were associated with a blunted infant cortisol response to a painful stressor. This relation persisted after evaluation of covariates including maternal sensitivity and maternal psychological distress. This study provides evidence that unpredictable patterns of maternal sensory signals are one process through which caregiving affects the function of infant stress response systems.
Sections du résumé
BACKGROUND
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with poor physical and mental health. Early-life adversity may dysregulate cortisol response to subsequent stress. This study examines the association between patterns of maternal behavior and infant stress response to a challenge. Specifically, we test whether infant exposure to unpredictable maternal sensory signals is related to the cortisol response to a painful stressor.
METHOD
Participants were 102 mothers and their children enrolled in a longitudinal study. Patterns of maternal sensory signals were evaluated at 6 and 12 months during a 10-min mother-infant play episode. Entropy rate was calculated as a quantitative measure of the degree of unpredictability of maternal sensory signals (visual, auditory, and tactile) exhibited during the play episode. Infant saliva samples were collected for cortisol analysis before and after inoculation at 12 months.
RESULTS
Unpredictable patterns of maternal sensory signals were associated with a blunted infant cortisol response to a painful stressor. This relation persisted after evaluation of covariates including maternal sensitivity and maternal psychological distress.
CONCLUSIONS
This study provides evidence that unpredictable patterns of maternal sensory signals are one process through which caregiving affects the function of infant stress response systems.
Identifiants
pubmed: 32115696
doi: 10.1002/dev.21964
pmc: PMC7822564
mid: NIHMS1570882
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
882-888Subventions
Organisme : NIH HHS
ID : NS041298
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD065823
Pays : United States
Organisme : NIMH NIH HHS
ID : R03 MH086062
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS041298
Pays : United States
Organisme : NIH HHS
ID : HD065823
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH096889
Pays : United States
Organisme : NIH HHS
ID : HD051852
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH015442
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD050662
Pays : United States
Organisme : NIMH NIH HHS
ID : T32MH015442
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD051852
Pays : United States
Organisme : NIH HHS
ID : HD02413
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH109662
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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