Pro-inflammatory cytokines favor the emergence of ETV6-RUNX1-positive pre-leukemic cells in a model of mesenchymal niche.
ALL
ETV6-RUNX1
MSC
inflammation
pre-leukemia
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
19
09
2019
revised:
19
12
2019
accepted:
13
01
2020
pubmed:
3
3
2020
medline:
3
3
2021
entrez:
3
3
2020
Statut:
ppublish
Résumé
ETV6-RUNX1 (E/R) fusion gene, arising in utero from translocation t(12;21)(p13:q22), is the most frequent alteration in childhood acute lymphoblastic leukemia (ALL). However, E/R is insufficient to cause overt leukemia since it generates a clinically silent pre-leukemic clone which persists in the bone marrow but fails to out-compete normal progenitors. Conversely, pre-leukemic cells show increased susceptibility to transformation following additional genetic insults. Infections/inflammation are the most accredited triggers for mutations accumulation and leukemic transformation in E/R
Substances chimiques
Core Binding Factor Alpha 2 Subunit
0
Cytokines
0
Oncogene Proteins, Fusion
0
TEL-AML1 fusion protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-273Subventions
Organisme : Asociación Española Contra el Cáncer, Beca FERO and the ISCIII/FEDER
ID : PI17/01028
Pays : International
Organisme : Fondazione Cariplo
ID : (2018-0339)
Pays : International
Organisme : Bianchi Industrial
Pays : International
Organisme : Catalunya Government
ID : SGR330 and PERIS 2017
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2014 Id.15494
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2018 Id. 21999
Pays : International
Organisme : Beat Leukemia Foundation
Pays : International
Organisme : Agencia Estatal de Investigación/European Regional Development Fund
ID : SAF2016-75442-R
Pays : International
Organisme : Agencia Estatal de Investigación/European Regional Development Fund
ID : SAF2016-80481-R
Pays : International
Organisme : Fondazione Tettamanti
Pays : International
Organisme : Società Italiana di Ematologia Sperimentale
Pays : International
Organisme : European Research Council
ID : CoG-2014-646903
Pays : International
Organisme : European Research Council
ID : PoC-2018-811220
Pays : International
Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
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