Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with
cholesterol
developmental biology
embryonic lethality
isoprenoid
mouse
vitamin K
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 03 2020
02 03 2020
Historique:
received:
02
01
2020
accepted:
02
03
2020
pubmed:
3
3
2020
medline:
10
4
2021
entrez:
3
3
2020
Statut:
epublish
Résumé
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4). Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway that produces cholesterol and essential nonsterol isoprenoids. Gene knockout studies were previously attempted to explore the function of UBIAD1 in mice; however, homozygous germ-line elimination of the
Identifiants
pubmed: 32118581
doi: 10.7554/eLife.54841
pii: 54841
pmc: PMC7069719
doi:
pii:
Substances chimiques
Hydroxymethylglutaryl CoA Reductases
EC 1.1.1.-
Dimethylallyltranstransferase
EC 2.5.1.1
Ubiad1 protein, mouse
EC 2.5.1.1
CRISPR-Associated Protein 9
EC 3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL020948
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM134700
Pays : United States
Organisme : U.S. Department of Agriculture
ID : 58-1950-7-707
Informations de copyright
© 2020, Jo et al.
Déclaration de conflit d'intérêts
YJ, SK, KG, IF, LD, JE, XF, SB, BE, RD No competing interests declared
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