Epstein-Barr virus-positive gastric cancer involves enhancer activation through activating transcription factor 3.
Activating Transcription Factor 3
/ genetics
Apoptosis
/ genetics
Binding Sites
Cell Line
Cell Proliferation
/ genetics
Enhancer Elements, Genetic
Epigenome
Epstein-Barr Virus Infections
/ genetics
Epstein-Barr Virus Nuclear Antigens
/ genetics
Gene Expression
Herpesvirus 4, Human
/ genetics
Humans
Mutation
Stomach Neoplasms
/ genetics
Transcriptome
Epstein-Barr virus
enhancer
epigenome
gastric cancer
transcription factor
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
10
12
2019
revised:
20
02
2020
accepted:
24
02
2020
pubmed:
3
3
2020
medline:
2
6
2020
entrez:
3
3
2020
Statut:
ppublish
Résumé
Epstein-Barr virus (EBV) is associated with particular forms of gastric cancer (GC). We previously showed that EBV infection into gastric epithelial cells induced aberrant DNA hypermethylation in promoter regions and silencing of tumor suppressor genes. We here undertook integrated analyses of transcriptome and epigenome alteration during EBV infection in gastric cells, to investigate activation of enhancer regions and related transcription factors (TFs) that could contribute to tumorigenesis. Formaldehyde-assisted isolation of regulatory elements (FAIRE) sequencing (-seq) data revealed 19 992 open chromatin regions in putative H3K4me1
Identifiants
pubmed: 32119176
doi: 10.1111/cas.14370
pmc: PMC7226279
doi:
Substances chimiques
ATF3 protein, human
0
Activating Transcription Factor 3
0
Epstein-Barr Virus Nuclear Antigens
0
EBV-encoded nuclear antigen 1
O5GA75RST7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1818-1828Subventions
Organisme : Japan Society for the Promotion of Science
ID : 16H05412
Organisme : Japan Society for the Promotion of Science
ID : 19H03726
Organisme : Japan Agency for Medical Research and Development
ID : 19ck0106263h0003
Organisme : Japan Agency for Medical Research and Development
ID : 19cm0106510h0004
Informations de copyright
© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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