The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.

Bacterial Vaccines / immunology Drug Resistance, Bacterial Gonorrhea / complications Neisseria gonorrhoeae / drug effects

Journal

Translational research : the journal of laboratory and clinical medicine
ISSN: 1878-1810
Titre abrégé: Transl Res
Pays: United States
ID NLM: 101280339

Informations de publication

Date de publication:
06 2020
Historique:
received: 26 12 2019
revised: 08 02 2020
accepted: 10 02 2020
pubmed: 3 3 2020
medline: 26 9 2020
entrez: 3 3 2020
Statut: ppublish

Résumé

The sexually transmitted infection gonorrhea, caused by the Gram-negative bacterium Neisseria gonorrhoeae, can cause urethritis, cervicitis, and systemic disease, among other manifestations. N. gonorrhoeae has rapidly rising incidence along with increasing levels of antibiotic resistance to a broad range of drugs including first-line treatments. The rise in resistance has led to fears of untreatable gonorrhea causing substantial disease globally. In this review, we will describe multiple approaches being undertaken to slow and control this spread of resistance. First, a number of old drugs have been repurposed and new drugs are being developed with activity against Neisseria gonorrhoeae. Second, vaccine development, long an important goal, is advancing. Third, new diagnostics promise rapid detection of antibiotic resistance and a shift from empiric to tailored treatment. The deployment of these new tools for addressing the challenge of antibiotic resistance will require careful consideration to provide optimal care for all patients while extending the lifespan of treatment regimens.

Identifiants

DOI: 10.1016/j.trsl.2020.02.002 PMID: 32119845 PMC: PMC7293957
pubmed: 32119845
pii: S1931-5244(20)30031-1
doi: 10.1016/j.trsl.2020.02.002
pmc: PMC7293957
mid: NIHMS1580697
pii:
doi:

Substances chimiques

Bacterial Vaccines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

122-137

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI132606
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007753
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

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Auteurs

Daniel H F Rubin (DHF)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Jonathan D C Ross (JDC)

Department of Sexual Health and HIV, Birmingham University Hospitals NHS Foundation Trust, Birmingham, UK.

Yonatan H Grad (YH)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: ygrad@hsph.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › The frontiers of addressing antibiotic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › The frontiers of addressing antibiotic...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Gonorrhée › The frontiers of addressing antibiotic...
questionsmedicales.fr › Bactéries › Proteobacteria › Betaproteobacteria › Neisseriaceae › Neisseria › Neisseria gonorrhoeae › The frontiers of addressing antibiotic...