In-Situ Forming pH and Thermosensitive Injectable Hydrogels to Stimulate Angiogenesis: Potential Candidates for Fast Bone Regeneration Applications.

Angiogenesis Inducing Agents / administration & dosage Animals Bone Regeneration / drug effects Chick Embryo Chitosan / chemistry Chorioallantoic Membrane / cytology Drug Carriers / chemistry Durapatite / chemistry Heparin / administration & dosage Hydrogels / chemical synthesis Hydrogen-Ion Concentration Microscopy, Electron, Scanning Neovascularization, Physiologic / drug effects Rheology Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Temperature
angiogenesis chitosan ex-ovo chick chorioallantoic membrane (CAM) assay heparin hydroxyapatite injectability thermosensitive injectable hydrogels

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
27 Feb 2020
Historique:
received: 17 12 2019
revised: 15 02 2020
accepted: 24 02 2020
entrez: 4 3 2020
pubmed: 4 3 2020
medline: 29 12 2020
Statut: epublish

Résumé

Biomaterials that promote angiogenesis are required for repair and regeneration of bone. In-situ formed injectable hydrogels functionalised with bioactive agents, facilitating angiogenesis have high demand for bone regeneration. In this study, pH and thermosensitive hydrogels based on chitosan (CS) and hydroxyapatite (HA) composite materials loaded with heparin (Hep) were investigated for their pro-angiogenic potential. Hydrogel formulations with varying Hep concentrations were prepared by sol-gel technique for these homogeneous solutions were neutralised with sodium bicarbonate (NaHCO

Identifiants

DOI: 10.3390/ijms21051633 PMID: 32120998 PMC: PMC7084557
pubmed: 32120998
pii: ijms21051633
doi: 10.3390/ijms21051633
pmc: PMC7084557
pii:
doi:

Substances chimiques

Angiogenesis Inducing Agents 0
Drug Carriers 0
Hydrogels 0
Heparin 9005-49-6
Chitosan 9012-76-4
Durapatite 91D9GV0Z28

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : TURKISH MINISTRY OF NATIONAL EDUCATION
ID : PhD studentship

Déclaration de conflit d'intérêts

The authors declare no conflict of interest. The funders had no role in the design of the study.

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Auteurs

Fatma Z Kocak (FZ)

Engineering Department, Lancaster University, Lancaster LA1 4YW, UK.
ORCID: 0000-0001-6397-322X

Abdullah C S Talari (ACS)

Engineering Department, Lancaster University, Lancaster LA1 4YW, UK.

Muhammad Yar (M)

Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Punjab 54000, Pakistan.

Ihtesham U Rehman (IU)

Engineering Department, Lancaster University, Lancaster LA1 4YW, UK.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Substances de croissance › Modulateurs d'angiogenèse › Agents angiogéniques › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Eucaryotes › Animaux › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Embryon de poulet › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Chorioallantoïde › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Héparine › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Microscopie électronique à balayage › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Rhéologie › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectrophotométrie › Spectrophotométrie IR › Spectroscopie infrarouge à transformée de Fourier › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Analyse spectrale Raman › In-Situ Forming pH and Thermosensitive...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › In-Situ Forming pH and Thermosensitive...