Environmental UVR Levels and Skin Pigmentation Gene Variants Associated with Folate and Homocysteine Levels in an Elderly Cohort.
folate
gene–nutrient–environment interactions
nutrigenetics
skin pigmentation
ultraviolet radiation
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
28 02 2020
28 02 2020
Historique:
received:
21
01
2020
revised:
26
02
2020
accepted:
26
02
2020
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Ultraviolet radiation (UVR) is a ubiquitous exposure which may contribute to decreased folate levels. Skin pigmentation mediates the biological effect of UVR exposure, but its relationship to folate levels is unexamined. Interactions may exist between UVR and pigmentation genes in determining folate status, which may, in turn, impact homocysteine levels, a potential risk factor for multiple chronic diseases. Therefore, independent and interactive influences of environmental UVR and genetic variants related to skin pigmentation (MC1R-rs1805007, IRF4-rs12203592 and HERC2-rs12913832) on folate (red blood cell (RBC) and serum) and homocysteine levels were examined in an elderly Australian cohort (n = 599). Genotypes were assessed by RT/RFLP-PCR, and UVR exposures were assessed as the accumulated erythemal dose rate accumulated over 4 months (4M-EDR). Multivariate analysis found significant negative associations between 4M-EDR and RBC folate (p < 0.001, β = -0.19), serum folate (p = 0.045, β = -0.08) and homocysteine levels (p < 0.001, β = -0.28). Significant associations between
Identifiants
pubmed: 32121219
pii: ijerph17051545
doi: 10.3390/ijerph17051545
pmc: PMC7084217
pii:
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Folic Acid
935E97BOY8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
Références
J Am Acad Dermatol. 2017 Nov;77(5):958-964
pubmed: 29029903
Clin Chem. 1998 Jan;44(1):102-7
pubmed: 9550566
J Clin Endocrinol Metab. 2014 Feb;99(2):633-8
pubmed: 24276459
Nutr J. 2006 Feb 10;5:5
pubmed: 16472386
Br J Nutr. 2016 Apr;115(8):1379-86
pubmed: 26887798
J Photochem Photobiol B. 2014 Feb 5;131:90-5
pubmed: 24509071
Nutr Rev. 2004 Jun;62(6 Pt 2):S3-12; discussion S13
pubmed: 15298442
Evol Med Public Health. 2014 Jan;2014(1):69-91
pubmed: 24699387
Photochem Photobiol. 2006 Nov-Dec;82(6):1651-5
pubmed: 16879038
Front Aging Neurosci. 2017 May 30;9:169
pubmed: 28611659
Am J Clin Nutr. 2001 Mar;73(3):613-21
pubmed: 11237940
Am J Clin Nutr. 1999 Mar;69(3):476-81
pubmed: 10075333
J Inherit Metab Dis. 2011 Feb;34(1):75-81
pubmed: 20814827
PLoS One. 2016 Aug 22;11(8):e0161368
pubmed: 27548258
J Invest Dermatol. 2017 Sep;137(9):1887-1894
pubmed: 28502801
BBA Clin. 2015 Jan 05;3:107-12
pubmed: 26673393
J Photochem Photobiol B. 2010 Nov 3;101(2):111-6
pubmed: 20207157
Dermatology. 2017;233(1):1-15
pubmed: 28463841
J Invest Dermatol. 2009 Sep;129(9):2250-7
pubmed: 19340012
Cell Biochem Funct. 2009 Jul;27(5):323-7
pubmed: 19472299
Am J Hum Genet. 2010 Jul 9;87(1):6-16
pubmed: 20602913
Science. 1978 Aug 18;201(4356):625-6
pubmed: 675247
J Nutr. 2004 Jul;134(7):1786-92
pubmed: 15226470
Am J Clin Nutr. 2005 Aug;82(2):442-50
pubmed: 16087991
Nutr Rev. 1999 Oct;57(10):314-21
pubmed: 10575908
Free Radic Biol Med. 2009 Oct 15;47(8):1199-204
pubmed: 19647791
Am J Clin Nutr. 2011 Aug;94(2):666S-72S
pubmed: 21733877
Am J Hum Biol. 2017 Mar;29(2):
pubmed: 27771938
N Am J Med Sci. 2016 Jul;8(7):284-90
pubmed: 27583236
Photochem Photobiol. 2005 Jul-Aug;81(4):736-49
pubmed: 15819599
Am J Clin Nutr. 2000 Nov;72(5):1156-63
pubmed: 11063443
Int J Vitam Nutr Res. 2001 May;71(3):173-8
pubmed: 11582839
Nat Genet. 2007 Dec;39(12):1443-52
pubmed: 17952075
J Pathol. 2007 Jan;211(2):241-51
pubmed: 17200942
Clin Chem. 2001 Aug;47(8):1430-6
pubmed: 11468233
Hum Mutat. 2007 May;28(5):495-505
pubmed: 17279550
J Invest Dermatol. 1979 Aug;73(2):141-3
pubmed: 88488
Int J Cancer. 2006 Dec 1;119(11):2597-602
pubmed: 16988943
Adv Nutr. 2011 Jul;2(4):325-31
pubmed: 22332074
J Am Acad Dermatol. 2010 Apr;62(4):710-1
pubmed: 20227588
Br J Nutr. 2010 Apr;103(8):1195-204
pubmed: 19968891
Lasers Med Sci. 2011 Jul;26(4):481-5
pubmed: 21344249
Photochem Photobiol Sci. 2008 Jul;7(7):814-8
pubmed: 18597029
J Am Acad Dermatol. 2009 Aug;61(2):259-62
pubmed: 19493587
J Nutrigenet Nutrigenomics. 2014;7(4-6):264-73
pubmed: 25969372
Biosci Biotechnol Biochem. 2009 Feb;73(2):322-7
pubmed: 19202297
Nutr J. 2004 May 10;3:4
pubmed: 15134582
Medicine (Baltimore). 2016 Feb;95(6):e2652
pubmed: 26871790
Int J Mol Sci. 2016 Oct 20;17(10):
pubmed: 27775595
Nat Protoc. 2008;3(9):1388-94
pubmed: 18772865
BMC Dermatol. 2001;1:8
pubmed: 11737876
Am J Clin Nutr. 2003 Apr;77(4):826-33
pubmed: 12663279
PLoS Genet. 2008 May 16;4(5):e1000074
pubmed: 18483556