The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK
Anaplastic Lymphoma Kinase
/ deficiency
Biopsy
Cell Line, Tumor
Cell Proliferation
Clonal Evolution
DNA Helicases
/ genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Silencing
Humans
Lymphoma, Large-Cell, Anaplastic
/ genetics
MicroRNAs
/ genetics
Models, Biological
Phenotype
Promoter Regions, Genetic
RNA Interference
RNA, Long Noncoding
Journal
Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
07
08
2019
accepted:
10
02
2020
revised:
20
01
2020
pubmed:
4
3
2020
medline:
1
12
2020
entrez:
4
3
2020
Statut:
ppublish
Résumé
The molecular mechanisms leading to the transformation of anaplastic lymphoma kinase negative (ALK
Identifiants
pubmed: 32123306
doi: 10.1038/s41375-020-0754-8
pii: 10.1038/s41375-020-0754-8
doi:
Substances chimiques
MicroRNAs
0
RNA, Long Noncoding
0
ALK protein, human
EC 2.7.10.1
Anaplastic Lymphoma Kinase
EC 2.7.10.1
DNA Helicases
EC 3.6.4.-
HELLS protein, human
EC 5.99.-
Banques de données
GENBANK
['MN902222']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2964-2980Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)
ID : 10007
Pays : International
Organisme : Leukemia and Lymphoma Society (Leukemia & Lymphoma Society)
ID : 7011-16
Pays : International
Organisme : Ministero della Salute (Ministry of Health, Italy)
ID : GR-2016-02364298
Pays : International
Références
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375–90.
pubmed: 26980727
pmcid: 4874220
doi: 10.1182/blood-2016-01-643569
Hapgood G, Savage KJ. The biology and management of systemic anaplastic large cell lymphoma. Blood. 2015;126:17–25.
pubmed: 25869285
doi: 10.1182/blood-2014-10-567461
Crescenzo R, Abate F, Lasorsa E, Tabbo F, Gaudiano M, Chiesa N, et al. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell. 2015;27:516–32.
pubmed: 25873174
pmcid: 5898430
doi: 10.1016/j.ccell.2015.03.006
Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, et al. ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014;124:1473–80.
pubmed: 24894770
pmcid: 4148769
doi: 10.1182/blood-2014-04-571091
Ferreri AJ, Govi S, Pileri SA, Savage KJ. Anaplastic large cell lymphoma, ALK-negative. Crit Rev Oncol Hematol. 2013;85:206–15.
pubmed: 22789917
doi: 10.1016/j.critrevonc.2012.06.004
Agnelli L, Mereu E, Pellegrino E, Limongi T, Kwee I, Bergaggio E, et al. Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma. Blood. 2012;120:1274–81.
pubmed: 22740451
doi: 10.1182/blood-2012-01-405555
Pizzi M, Gaudiano M, Todaro M, Inghirami G. Anaplastic lymphoma kinase: activating mechanisms and signaling pathways. Front Biosci. 2015;7:283–305.
doi: 10.2741/s441
Savage KJ, Harris NL, Vose JM, Ullrich F, Jaffe ES, Connors JM, et al. ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project. Blood. 2008;111:5496–504.
Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbo F, et al. PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood. 2013;122:2683–93.
pubmed: 24004669
doi: 10.1182/blood-2013-04-497933
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, et al. Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma. Blood. 2014;123:2915–23.
pubmed: 24632715
pmcid: 4014836
doi: 10.1182/blood-2013-11-536359
Scarfo I, Pellegrino E, Mereu E, Kwee I, Agnelli L, Bergaggio E, et al. Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts. Blood. 2016;127:221–32.
pubmed: 26463425
doi: 10.1182/blood-2014-12-614503
Chiarle R, Simmons WJ, Cai H, Dhall G, Zamo A, Raz R, et al. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med. 2005;11:623–9.
pubmed: 15895073
doi: 10.1038/nm1249
Wang H, Huo X, Yang XR, He J, Cheng L, Wang N, et al. STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 2017;16:136.
pubmed: 28810927
pmcid: 5558651
doi: 10.1186/s12943-017-0680-1
Zhao J, Du P, Cui P, Qin Y, Hu C, Wu J, et al. LncRNA PVT1 promotes angiogenesis via activating the STAT3/VEGFA axis in gastric cancer. Oncogene. 2018;37:4094–109.
doi: 10.1038/s41388-018-0250-z
pubmed: 29706652
Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018 ;172:393–407.
pubmed: 29373828
pmcid: 5978744
doi: 10.1016/j.cell.2018.01.011
Schmitt AM, Chang HY. Long noncoding RNAs in cancer pathways. Cancer Cell. 2016;29:452–63.
pubmed: 27070700
pmcid: 4831138
doi: 10.1016/j.ccell.2016.03.010
Aune TM, Crooke PS,III, Spurlock CF 3rd. Long noncoding RNAs in T lymphocytes. J Leukoc Biol. 2016;99:31–44.
pubmed: 26538526
doi: 10.1189/jlb.1RI0815-389R
Casero D, Sandoval S, Seet CS, Scholes J, Zhu Y, Ha VL, et al. Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nat Immunol. 2015;16:1282–91.
pubmed: 26502406
pmcid: 4653072
doi: 10.1038/ni.3299
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal RJ, Curti S, et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol. 2015;16:318–25.
pubmed: 25621826
pmcid: 4333215
doi: 10.1038/ni.3093
Collier SP, Henderson MA, Tossberg JT, Aune TM. Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet. J Immunol. 2014;193:3959–65.
pubmed: 25225667
doi: 10.4049/jimmunol.1401099
Spurlock CF III, Tossberg JT, Guo Y, Collier SP, Crooke PS III, Aune TM. Expression and functions of long noncoding RNAs during human T helper cell differentiation. Nat Commun. 2015;6:6932.
pubmed: 25903499
doi: 10.1038/ncomms7932
Koh BH, Hwang SS, Kim JY, Lee W, Kang MJ, Lee CG, et al. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci USA. 2010;107:10614–9.
pubmed: 20483988
doi: 10.1073/pnas.1005383107
pmcid: 2890814
Baytak E, Gong Q, Akman B, Yuan H, Chan WC, Kucuk C. Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1. Tumour Biol. 2017;39:1010428317701648.
pubmed: 28468592
doi: 10.1177/1010428317701648
Chung IH, Lu PH, Lin YH, Tsai MM, Lin YW, Yeh CT, et al. The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma. Sci Rep. 2017;7:295.
pubmed: 28331184
pmcid: 5428265
doi: 10.1038/s41598-017-00382-7
Huang PS, Chung IH, Lin YH, Lin TK, Chen WJ, Lin KH. The Long non coding RNA MIR503HG enhances proliferation of human ALK-negative anaplastic large-cell lymphoma. Int J Mol Sci. 2018; 19:1463.
Fragliasso V, Chiodo Y, Ferrari-Amorotti G, Soliera AR, Manzotti G, Cattelani S, et al. Phosphorylation of serine 21 modulates the proliferation inhibitory more than the differentiation inducing effects of C/EBPalpha in K562 cells. J Cell Biochem. 2012;113:1704–13.
pubmed: 22212957
pmcid: 3329570
Sancisi V, Manzotti G, Gugnoni M, Rossi T, Gandolfi G, Gobbi G, et al. RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN. Nucleic Acids Res. 2017;45:11249–67.
Gugnoni M, Sancisi V, Gandolfi G, Manzotti G, Ragazzi M, Giordano D, et al. Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene. 2016;36:667.
pubmed: 27375021
doi: 10.1038/onc.2016.237
Verma A, Jiang Y, Du W, Fairchild L, Melnick A, Elemento O. Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma. Genome Med. 2015;7:110.
pubmed: 26521025
pmcid: 4628784
doi: 10.1186/s13073-015-0230-7
Fededa JP, Gerlich DW. Molecular control of animal cell cytokinesis. Nat Cell Biol. 2012;14:440–7.
pubmed: 22552143
doi: 10.1038/ncb2482
Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, et al. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014;28:1363–79.
pubmed: 24939938
pmcid: 4066405
doi: 10.1101/gad.238782.114
Werner MS, Sullivan MA, Shah RN, Nadadur RD, Grzybowski AT, Galat V, et al. Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription. Nat Struct Mol Biol. 2017;24:596–603.
pubmed: 28628087
pmcid: 5682930
doi: 10.1038/nsmb.3424
Engreitz JM, Ollikainen N, Guttman M. Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression. Nat Rev Mol Cell Biol. 2016;17:756.
pubmed: 27780979
doi: 10.1038/nrm.2016.126
Geiman TM, Muegge K. Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Proc Natl Acad Sci USA. 2000;97:4772–7.
pubmed: 10781083
doi: 10.1073/pnas.97.9.4772
pmcid: 18308
Tao Y, Liu S, Briones V, Geiman TM, Muegge K. Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS. Nucleic Acids Res. 2011;39:9508–20.
pubmed: 21880597
pmcid: 3239205
doi: 10.1093/nar/gkr611
Tao Y, Xi S, Briones V, Muegge K. Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation. PLoS ONE. 2010;5:e9163.
pubmed: 20161795
pmcid: 2820093
doi: 10.1371/journal.pone.0009163
Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, et al. Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome. Nat Commun. 2015;6:7870.
pubmed: 26216346
doi: 10.1038/ncomms8870
von Eyss B, Maaskola J, Memczak S, Mollmann K, Schuetz A, Loddenkemper C, et al. The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. EMBO J. 2012;31:972–85.
doi: 10.1038/emboj.2011.451
Xi S, Zhu H, Xu H, Schmidtmann A, Geiman TM, Muegge K. Lsh controls Hox gene silencing during development. Proc Natl Acad Sci USA. 2007;104:14366–71.
pubmed: 17726103
doi: 10.1073/pnas.0703669104
pmcid: 1955459
Orom UA, Shiekhattar R. Long noncoding RNAs usher in a new era in the biology of enhancers. Cell. 2013;154:1190–3.
pubmed: 24034243
pmcid: 4108076
doi: 10.1016/j.cell.2013.08.028
Wang R, Shi Y, Chen L, Jiang Y, Mao C, Yan B, et al. The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH. Sci Rep. 2015;5:17826.
pubmed: 26658322
pmcid: 4675985
doi: 10.1038/srep17826
Pizzi M, Margolskee E, Inghirami G. Pathogenesis of Peripheral T Cell Lymphoma. Annu Rev Pathol. 2018;13:293–320.
pubmed: 29414251
doi: 10.1146/annurev-pathol-020117-043821
Zeng Y, Feldman AL. Genetics of anaplastic large cell lymphoma. Leuk Lymphoma. 2016;57:21–27.
pubmed: 26104084
doi: 10.3109/10428194.2015.1064530
Nobili L, Ronchetti D, Taiana E, Neri A. Long non-coding RNAs in B-cell malignancies: a comprehensive overview. Oncotarget. 2017;8:60605–23.
pubmed: 28947998
pmcid: 5601166
doi: 10.18632/oncotarget.17303
Lee CS, Ungewickell A, Bhaduri A, Qu K, Webster DE, Armstrong R, et al. Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts. Blood. 2012;120:3288–97.
pubmed: 22936659
pmcid: 3476540
doi: 10.1182/blood-2012-04-423061
Piva R, Agnelli L, Pellegrino E, Todoerti K, Grosso V, Tamagno I, et al. Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms. J Clin Oncol. 2010;28:1583–90.
pubmed: 20159827
doi: 10.1200/JCO.2008.20.9759
Huynh J, Etemadi N, Hollande F, Ernst M, Buchert M. The JAK/STAT3 axis: a comprehensive drug target for solid malignancies. Semin Cancer Biol. 2017;45:13–22.
pubmed: 28647610
doi: 10.1016/j.semcancer.2017.06.001
Zamo A, Chiarle R, Piva R, Howes J, Fan Y, Chilosi M, et al. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene. 2002;21:1038–47.
pubmed: 11850821
doi: 10.1038/sj.onc.1205152
Rastogi P, Deva AK, Prince HM. Breast Implant-associated anaplastic large cell lymphoma. Curr Hematol Malig Rep. 2018;13:516–24.
pubmed: 30345474
doi: 10.1007/s11899-018-0478-2
Kucuk C, Jiang B, Hu X, Zhang W, Chan JK, Xiao W, et al. Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells. Nat Commun. 2015;6:6025.
pubmed: 25586472
doi: 10.1038/ncomms7025
Hammaren HM, Virtanen AT, Raivola J, Silvennoinen O. The regulation of JAKs in cytokine signaling and its breakdown in disease. Cytokine. 2019;118:48–63.
Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, et al. Role of long non-coding RNAs in glucose metabolism in cancer. Mol Cancer. 2017;16:130.
pubmed: 28738810
pmcid: 5525357
doi: 10.1186/s12943-017-0699-3
Debidda M, Wang L, Zang H, Poli V, Zheng Y. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. J Biol Chem. 2005;280:17275–85.
pubmed: 15705584
doi: 10.1074/jbc.M413187200
Teng TS, Lin B, Manser E, Ng DC, Cao X. Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX. J Cell Sci. 2009;122:4150–9.
pubmed: 19861492
doi: 10.1242/jcs.057109
Lungu C, Muegge K, Jeltsch A, Jurkowska RZ. An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin. J Mol Biol. 2015;427:1903–15.
pubmed: 25823553
doi: 10.1016/j.jmb.2015.03.014
pmcid: 7722765
Han Y, Ren J, Lee E, Xu X, Yu W, Muegge K. Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells. Sci Rep. 2017;7:1136.
pubmed: 28442710
pmcid: 5430779
doi: 10.1038/s41598-017-00804-6
Zhang G, Dong Z, Prager BC, Kim LJ, Wu Q, Gimple RC, et al. Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC. JCI Insight. 2019;4:e126140.
He X, Yan B, Liu S, Jia J, Lai W, Xin X, et al. Chromatin remodeling factor LSH drives cancer progression by suppressing the activity of fumarate hydratase. Cancer Res. 2016;76:5743–55.
pubmed: 27302170
doi: 10.1158/0008-5472.CAN-16-0268
pmcid: 7821962
Behan FM, Iorio F, Picco G, Goncalves E, Beaver CM, Migliardi G, et al. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature. 2019; 568:511–16.