Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases.
Algorithms
Alleles
Computational Biology
/ methods
Gene Expression Regulation
Genetic Loci
Genome-Wide Association Study
Glycosylation
Humans
Immunoglobulin G
/ immunology
Inflammation
/ genetics
Linkage Disequilibrium
Models, Genetic
Phenotype
Polymorphism, Single Nucleotide
Polysaccharides
/ metabolism
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
15
02
2019
accepted:
19
11
2019
entrez:
5
3
2020
pubmed:
5
3
2020
medline:
23
10
2020
Statut:
epublish
Résumé
Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been observed in many diseases, but little is understood about the underlying mechanisms. We performed a genome-wide association study of IgG N-glycosylation (
Identifiants
pubmed: 32128391
doi: 10.1126/sciadv.aax0301
pii: aax0301
pmc: PMC7030929
doi:
Substances chimiques
Immunoglobulin G
0
Polysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaax0301Subventions
Organisme : Cancer Research UK
ID : 12076
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CZB/4/710
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600329
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R026408/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600237
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : ETM/47
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_U127527198
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U127527198
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K018647/1
Pays : United Kingdom
Organisme : Worldwide Cancer Research
ID : 12-1087
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
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