Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study.
Japanese patients
health-related quality of life
prostate cancer
proton beam therapy
Journal
Japanese journal of clinical oncology
ISSN: 1465-3621
Titre abrégé: Jpn J Clin Oncol
Pays: England
ID NLM: 0313225
Informations de publication
Date de publication:
05 May 2020
05 May 2020
Historique:
received:
20
12
2019
revised:
27
01
2020
accepted:
05
02
2020
pubmed:
5
3
2020
medline:
11
7
2020
entrez:
5
3
2020
Statut:
ppublish
Résumé
Many treatment options have guaranteed long-term survival in patients with localized prostate cancer and health-related quality of life has become a greater concern for those patients. The purpose of this study was to reveal the health-related quality of life after proton beam therapy and to clarify the differences from other treatment modalities for prostate cancer. Between January 2011 and April 2016, 583 patients were enrolled in the study and health-related quality of life outcomes using the Expanded Prostate Cancer Index Composite questionnaire were evaluated and compared with previous research targeted at Japanese patients. We found a significant decrease in the least square mean scores for urinary and bowel domains excluding the incontinence subscale after proton beam therapy (P < 0.0001) and recovery at a year following treatment. The scores for sexual function in patients without androgen deprivation therapy decreased each year after proton beam therapy (P < 0.0001). The scores for hormones in patients without androgen deprivation therapy remained high and those of patients with androgen deprivation therapy were lower before treatment but were comparable to those of non-androgen deprivation therapy patients at 2 years post-treatment. We found that the impact of radiotherapy including proton beam therapy on urinary condition and sexual function was lower than that of surgery. For the first time in Japan, we investigated health-related quality of life using Expanded Prostate Cancer Index Composite questionnaires in patients with prostate cancer after proton beam therapy and compared it with other treatment modalities.
Identifiants
pubmed: 32129447
pii: 5780070
doi: 10.1093/jjco/hyaa027
pmc: PMC7202140
doi:
Substances chimiques
Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
519-527Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
Références
Clin Genitourin Cancer. 2017 Dec;15(6):704-710
pubmed: 28412047
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):422-434
pubmed: 27084658
Int J Urol. 2017 Jul;24(7):518-524
pubmed: 28455847
N Engl J Med. 2008 Mar 20;358(12):1250-61
pubmed: 18354103
Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):946-53
pubmed: 24139077
Acta Oncol. 2018 May;57(5):582-588
pubmed: 29359988
Rep Pract Oncol Radiother. 2016 May-Jun;21(3):207-12
pubmed: 27601952
Eur Urol. 2017 Dec;72(6):869-885
pubmed: 28757301
Cancer. 2014 Apr 1;120(7):1076-82
pubmed: 24382757
Jpn J Clin Oncol. 2009 Aug;39(8):502-8
pubmed: 19477898
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):744-51
pubmed: 17904306
Cancer Med. 2017 Oct;6(10):2234-2243
pubmed: 28879658
Clin Genitourin Cancer. 2018 Apr;16(2):135-141.e1
pubmed: 29051056
J Robot Surg. 2020 Apr;14(2):255-260
pubmed: 31119473
Res Rep Urol. 2018 Oct 23;10:169-180
pubmed: 30425973
Jpn J Clin Oncol. 2014 Jul;44(7):686-91
pubmed: 24791781
J Robot Surg. 2016 Sep;10(3):201-7
pubmed: 26885662
Cancer Med. 2018 Mar;7(3):677-689
pubmed: 29441697
Qual Life Res. 2014 Jun;23(5):1641-50
pubmed: 24338068
Health Qual Life Outcomes. 2018 Jan 5;16(1):7
pubmed: 29304808
Cancer. 2012 Sep 15;118(18):4619-26
pubmed: 22253020
N Engl J Med. 2016 Oct 13;375(15):1425-1437
pubmed: 27626365
Int J Clin Oncol. 2018 Feb;23(1):165-172
pubmed: 28758177
N Engl J Med. 2016 Oct 13;375(15):1415-1424
pubmed: 27626136
J Robot Surg. 2017 Sep;11(3):325-331
pubmed: 28130703
JAMA Netw Open. 2018 Nov 2;1(7):e185293
pubmed: 30646397
Urology. 2000 Dec 20;56(6):899-905
pubmed: 11113727
Int J Clin Oncol. 2014 Dec;19(6):1092-7
pubmed: 24370729
Cancer. 2013 May 1;119(9):1729-35
pubmed: 23436283
Radiology. 1946 Nov;47(5):487-91
pubmed: 20274616
Cancer. 2008 Jan 1;112(1):55-60
pubmed: 17968996
Cancers (Basel). 2018 Apr 10;10(4):
pubmed: 29642619
Jpn J Clin Oncol. 2015 Jan;45(1):81-7
pubmed: 25425700
Prostate Int. 2018 Mar;6(1):7-11
pubmed: 29556483
Eur Urol. 2015 May;67(5):825-36
pubmed: 25097095
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):435-443
pubmed: 27084659
Nihon Hinyokika Gakkai Zasshi. 2005 Nov;96(7):657-69
pubmed: 16363651