The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections.

Animals Disease Models, Animal Female HLA-A2 Antigen / genetics HLA-C Antigens HLA-DR4 Antigen Homeodomain Proteins Hong Kong Humans Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza, Human Lung Mice Mice, Inbred NOD Orthomyxoviridae Infections
CD103 lung-resident T cells Humanized mouse IAV gender-based resilience natural IAV transmission pro-coagulation Factor 8 mRNA

Journal

Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652

Informations de publication

Date de publication:
01 09 2020
Historique:
pubmed: 5 3 2020
medline: 22 6 2021
entrez: 5 3 2020
Statut: ppublish

Résumé

We have engineered a Human Immune System (HIS)-reconstituted mouse strain (DRAGA mouse: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD) in which the murine immune system has been replaced by a long-term, functional HIS via infusion of CD34

Identifiants

DOI: 10.1080/21645515.2020.1713605 PMID: 32129705 PMC: PMC7553695
pubmed: 32129705
doi: 10.1080/21645515.2020.1713605
pmc: PMC7553695
doi:

Substances chimiques

HLA-A2 Antigen 0
HLA-C Antigens 0
HLA-DR4 Antigen 0
Homeodomain Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2222-2237

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL130448
Pays : United States

Références

J Immunol Methods. 2014 Aug;410:3-17
pubmed: 24607601
Bone Marrow Transplant. 2016 Apr;51(4):596-7
pubmed: 26595075
Science. 2012 Jun 22;336(6088):1534-41
pubmed: 22723413
Front Immunol. 2018 Apr 30;9:816
pubmed: 29760694
FEMS Immunol Med Microbiol. 2003 Mar 20;35(2):141-6
pubmed: 12628550
PLoS One. 2010 Apr 13;5(4):e10152
pubmed: 20405007
Semin Immunopathol. 2019 Mar;41(2):189-194
pubmed: 30298431
J Leukoc Biol. 2014 Feb;95(2):215-24
pubmed: 24006506
J Virol. 2015 Jul;89(13):6528-31
pubmed: 25878098
Curr Top Microbiol Immunol. 2014;378:129-47
pubmed: 24728596
Nat Med. 2012 Jan 29;18(2):274-80
pubmed: 22286307
PLoS One. 2008;3(12):e3942
pubmed: 19079604
J Bacteriol. 1940 Mar;39(3):229-41
pubmed: 16560287
EBioMedicine. 2017 Nov;25:87-94
pubmed: 29033368
Front Immunol. 2019 Jun 25;10:1457
pubmed: 31316510
Science. 2006 Apr 21;312(5772):399
pubmed: 16556800
Malar J. 2014 Sep 30;13:386
pubmed: 25266106
J Virol. 2006 Aug;80(15):7469-80
pubmed: 16840327
Comp Immunol Microbiol Infect Dis. 2016 Dec;49:29-38
pubmed: 27865261
Microbiol Mol Biol Rev. 2000 Dec;64(4):709-24
pubmed: 11104816
J Biol Chem. 2006 Apr 7;281(14):8997-9000
pubmed: 16407184
J Exp Med. 2011 Jan 17;208(1):181-93
pubmed: 21220454
Am J Epidemiol. 2006 Jan 15;163(2):181-7
pubmed: 16319291
Nat Struct Mol Biol. 2004 Jun;11(6):567-73
pubmed: 15122347
Front Immunol. 2018 Mar 26;9:515
pubmed: 29632527
J Exp Med. 1967 Mar 1;125(3):479-88
pubmed: 6016901
Sci Rep. 2018 May 9;8(1):7392
pubmed: 29743556
Blood. 2014 Jun 12;123(24):3697-705
pubmed: 24719406
Hum Vaccin Immunother. 2018 Feb 1;14(2):345-360
pubmed: 29135340
Influenza Other Respir Viruses. 2013 Sep;7(5):761-5
pubmed: 23279922
Nature. 2006 Mar 23;440(7083):435-6
pubmed: 16554799
J Gen Virol. 2016 Sep;97(9):2104-2116
pubmed: 27260213
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):869-74
pubmed: 24367114
Viruses. 2016 Apr 16;8(4):102
pubmed: 27092522
Nature. 1962 Sep 15;195:1129-30
pubmed: 13909471
J Virol. 2014 Aug;88(15):8375-85
pubmed: 24829357
Blood. 2014 Jun 12;123(24):3706-13
pubmed: 24705491
PLoS Pathog. 2010 Feb 26;6(2):e1000796
pubmed: 20195520
PLoS One. 2011;6(5):e19826
pubmed: 21611197
Curr Opin Immunol. 2013 Jun;25(3):403-9
pubmed: 23628166
Virus Res. 2014 Jun 24;185:53-63
pubmed: 24675275
Clin Cancer Res. 2008 Feb 15;14(4):1138-49
pubmed: 18281548
J Virol. 2007 Oct;81(19):10558-66
pubmed: 17634234
Science. 1998 Jan 16;279(5349):393-6
pubmed: 9430591
Sci Rep. 2016 Jun 21;6:28093
pubmed: 27323875
Biochemistry. 1991 Oct 29;30(43):10363-70
pubmed: 1931959
Immunity. 2013 Nov 14;39(5):939-48
pubmed: 24238342
J Virol. 2005 Sep;79(18):11788-800
pubmed: 16140756
MMWR Morb Mortal Wkly Rep. 2010 Aug 27;59(33):1057-62
pubmed: 20798667
Blood. 2010 May 6;115(18):3704-7
pubmed: 20207983
J Virol. 2014 May;88(9):4711-20
pubmed: 24522912
Nat Rev Microbiol. 2011 Jul 11;9(8):590-603
pubmed: 21747392
Blood Adv. 2016 Dec 14;1(3):231-239
pubmed: 29296938
Curr Opin Virol. 2016 Feb;16:132-142
pubmed: 26974887
Front Immunol. 2017 Oct 27;8:1405
pubmed: 29163484
J Virol. 1999 Jul;73(7):5903-11
pubmed: 10364342
Respir Care. 2010 May;55(5):623-5
pubmed: 20420734
Virology. 2013 Nov;446(1-2):349-56
pubmed: 24074599
J Immunol. 2005 Aug 15;175(4):2741-53
pubmed: 16081852
J Leukoc Biol. 2012 Jul;92(1):67-73
pubmed: 22131346
J Exp Med. 1963 Aug 1;118:267-75
pubmed: 14074390
PLoS One. 2016 Apr 18;11(4):e0153579
pubmed: 27088239
Nat Commun. 2018 Dec 21;9(1):5427
pubmed: 30575715
J Clin Invest. 2018 Feb 1;128(2):721-733
pubmed: 29309047
Respir Res. 2007 Oct 25;8:73
pubmed: 17961210
PLoS One. 2018 Sep 7;13(9):e0202675
pubmed: 30192789
Virology. 2011 Mar 15;411(2):229-36
pubmed: 21237476
Virology. 2013 Jan 5;435(1):14-28
pubmed: 23217612

Auteurs

Mirian Mendoza (M)

Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.
Department of Pathology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.

Devi Gunasekera (D)

Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.

Kathleen P Pratt (KP)

Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.
ORCID: 0000-0001-6837-6133

Qi Qiu (Q)

Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.
US Military Malaria Vaccine Development, Naval Medical Research Center/Walter Reed Army Institute of Research , Silver Spring, MD, USA.

Sofia Casares (S)

Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.
US Military Malaria Vaccine Development, Naval Medical Research Center/Walter Reed Army Institute of Research , Silver Spring, MD, USA.

Teodor-D Brumeanu (TD)

Department of Medicine, Division of Immunology, Uniformed Services University of the Health Sciences , Bethesda, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-A › Antigène HLA-A2 › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-C › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DR › Sous-types sérologiques HLA-DR › Antigène HLA-DR4 › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Hong Kong › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H1N1 du virus de la grippe A › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H3N2 du virus de la grippe A › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Appareil respiratoire › Poumon › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › The humanized DRAGA mouse (HLA-A2. HLA-DR4....
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Orthomyxoviridae › The humanized DRAGA mouse (HLA-A2. HLA-DR4....