Methods for the reliable induction of heterotopic ossification in the conditional

Activin Receptors, Type I / genetics Animals Cardiotoxins / toxicity Hindlimb / diagnostic imaging Mice Mice, Transgenic Muscle, Skeletal / diagnostic imaging Ossification, Heterotopic / chemically induced Reproducibility of Results
Acvr1/ALK2 BMP Fibrodysplasia Ossificans Progressiva Mouse Model Muscle Injury

Journal

Journal of musculoskeletal & neuronal interactions
ISSN: 1108-7161
Titre abrégé: J Musculoskelet Neuronal Interact
Pays: Greece
ID NLM: 101084496

Informations de publication

Date de publication:
03 03 2020
Historique:
entrez: 6 3 2020
pubmed: 7 3 2020
medline: 12 6 2021
Statut: ppublish

Résumé

Conditional Varying doses of Adex-cre and cardiotoxin (CTX) were injected into the calf muscles of 9, 14, or 28-day-old In 9-day-old These data illustrate multiple methods for reliable induction of localized HO in the

Identifiants

PMID: 32131380 PMC: PMC7104591
pubmed: 32131380
pmc: PMC7104591

Substances chimiques

Cardiotoxins 0
Activin Receptors, Type I EC 2.7.11.30
Acvr1 protein, mouse EC 2.7.11.30

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

149-159

Subventions

Organisme : BLRD VA
ID : IK2 BX001634
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE020843
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR067901
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027631
Pays : United States

Déclaration de conflit d'intérêts

Dr. Charles Hong reports grants, personal fees and other from La Jolla Pharmaceutical Company, during the conduct of the study; In addition, Dr. Charles Hong has a patent Fused heterocyclic compounds as selective BMP inhibitors licensed to La Jolla Pharmaceutical Co. Yuji Mishina receives research grant money from NIH and AMED (a funding agency in Japan). Dr. Daniel Perrien reports grants from NIH, grants from the Department of Veterans Affairs during the conduct of the study. Haichun Pan and Nicole Fleming have nothing to disclose.

Références

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Auteurs

Haichun Pan (H)

University of Michigan School of Dentistry, Ann Arbor, MI.

Nicole Fleming (N)

Vanderbilt Center for Bone Biology.

Charles C Hong (CC)

Vanderbilt Center for Bone Biology.
Department of Pharmacology.
Division of Cardiology in the Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville TN.

Yuji Mishina (Y)

University of Michigan School of Dentistry, Ann Arbor, MI.

Daniel S Perrien (DS)

Vanderbilt Center for Bone Biology.
Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville TN.
Division of Clinical Pharmacology in the Department of Medicine.
Center for Small Animal Imaging, Vanderbilt University Institute of Imaging Sciences, Vanderbilt University Medical Center, Nashville, TN.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs TGF-bêta › Récepteur activine › Récepteur activine, type 1 › Methods for the reliable induction of...
questionsmedicales.fr › Eucaryotes › Animaux › Methods for the reliable induction of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Cardiotoxines › Methods for the reliable induction of...
questionsmedicales.fr › Structures anatomiques de l'animal › Membre pelvien › Methods for the reliable induction of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Methods for the reliable induction of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Methods for the reliable induction of...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Methods for the reliable induction of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ossification hétérotopique › Methods for the reliable induction of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Methods for the reliable induction of...