Resveratrol binding to human complement fragment 5a (

Resveratrol (RSV), the active pharmaceutical ingredient (API) found in several fruits, nuts and marketed nutraceuticals is one of the promiscuous phytoalexin known to promote good health. The health benefits of RSV could be due to its antioxidant activity or its direct interaction with target proteins, resulting modulation of several cells signaling and inflammatory pathways. Among many of its disease preventing activities, RSV has been shown to ameliorate inflammation by directly binding the COX-1 and COX-2 enzymes, the established targets of common non-steroidal anti-inflammatory drugs (NSAIDs). As a follow up to our recent study, we have now identified that RSV can also directly target