Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis.
Age of Onset
Anti-Bacterial Agents
/ therapeutic use
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1
/ epidemiology
Female
Humans
Infant
Infant, Newborn
Male
Otitis Media
/ complications
Respiratory Tract Infections
/ complications
Risk Factors
Siblings
Sweden
/ epidemiology
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
12
06
2019
accepted:
04
02
2020
pubmed:
7
3
2020
medline:
6
3
2021
entrez:
6
3
2020
Statut:
ppublish
Résumé
The effect of early-life antibiotic treatment on the risk of type 1 diabetes is debated. This study assessed this question, applying a register-based design in children up to age 10 years including a large sibling-control analysis. All singleton children ( Type 1 diabetes developed in 1,297 children during the follow-up (median 4.0 years [range 0-8.3]). Prescribed antibiotics in the 1st year of life (23.8%) were associated with an increased risk of type 1 diabetes (adjusted hazard ratio [HR] 1.19 [95% CI 1.05-1.36]), with larger effect estimates among children delivered by cesarean section ( Dispensed prescription of antibiotics, mainly for acute otitis media and respiratory tract infections, in the 1st year of life is associated with an increased risk of type 1 diabetes before age 10 years, most prominently in children delivered by cesarean section.
Identifiants
pubmed: 32132008
pii: dc19-1162
doi: 10.2337/dc19-1162
pmc: PMC7171951
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
991-999Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 by the American Diabetes Association.
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