Human Glioma Cells Acquire Temozolomide Resistance After Repeated Drug Exposure
DNA mismatch repair
G2 checkpoint
Temozolomide
glioblastoma
resistance
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
03
02
2020
revised:
10
02
2020
accepted:
11
02
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
16
4
2020
Statut:
ppublish
Résumé
Temozolomide (TMZ) induces prolonged arrest of human glioma cells in the G To clarify the mechanism of TMZ resistance, we established TMZ-resistant (TR) clones by serial treatment of U87MG cells with TMZ. We evaluated TMZ-induced cell cycle arrest and the effect of various G We observed that longer exposure (over 6 months) to TMZ enriched the proportion of TR clones that underwent only minimal G Longer drug treatment may induce resistance of cells to DNA damaging agent(s) by means of mismatch repair modification.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Temozolomide (TMZ) induces prolonged arrest of human glioma cells in the G
MATERIALS AND METHODS
METHODS
To clarify the mechanism of TMZ resistance, we established TMZ-resistant (TR) clones by serial treatment of U87MG cells with TMZ. We evaluated TMZ-induced cell cycle arrest and the effect of various G
RESULTS
RESULTS
We observed that longer exposure (over 6 months) to TMZ enriched the proportion of TR clones that underwent only minimal G
CONCLUSION
CONCLUSIONS
Longer drug treatment may induce resistance of cells to DNA damaging agent(s) by means of mismatch repair modification.
Identifiants
pubmed: 32132028
pii: 40/3/1315
doi: 10.21873/anticanres.14073
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
Temozolomide
YF1K15M17Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1315-1323Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.