Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.
24S,25-epoxycholesterol
24S-hydroxycholesterol
brain
cholesterol
liquid chromatography-mass spectrometry
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
17 03 2020
17 03 2020
Historique:
pubmed:
7
3
2020
medline:
4
7
2020
entrez:
6
3
2020
Statut:
ppublish
Résumé
Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol metabolism in brain and the resulting sterol distributions are poorly defined. To better understand cholesterol metabolism in situ across the complex functional regions of brain, we have developed on-tissue enzyme-assisted derivatization in combination with microliquid extraction for surface analysis and liquid chromatography-mass spectrometry to locate sterols in tissue slices (10 µm) of mouse brain. The method provides sterolomic analysis at 400-µm spot diameter with a limit of quantification of 0.01 ng/mm
Identifiants
pubmed: 32132201
pii: 1917421117
doi: 10.1073/pnas.1917421117
pmc: PMC7084107
doi:
Substances chimiques
Hydroxycholesterols
0
24-hydroxycholesterol
47IMW63S3F
24,25-epoxycholesterol
68138-65-8
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5749-5760Subventions
Organisme : NEI NIH HHS
ID : P30 EY011373
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067552
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM062882
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I001735/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015932/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L001942/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: Y.W. and W.J.G. are listed as inventors on the patent “Kit and method for quantitative detection of steroids” US9851368B2.
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