Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
14
09
2018
revised:
19
09
2019
accepted:
21
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
The timing and location of the establishment of the viral reservoir during acute HIV infection remain unclear. Using longitudinal blood and tissue samples obtained from HIV-infected individuals at the earliest stage of infection, we demonstrate that frequencies of infected cells reach maximal values in gut-associated lymphoid tissue and lymph nodes as early as Fiebig stage II, before seroconversion. Both tissues displayed higher frequencies of infected cells than blood until Fiebig stage III, after which infected cells were equally distributed in all compartments examined. Initiation of antiretroviral therapy (ART) at Fiebig stages I to III led to a profound decrease in the frequency of infected cells to nearly undetectable level in all compartments. The rare infected cells that persisted were preferentially found in the lymphoid tissues. Initiation of ART at later stages (Fiebig stages IV/V and chronic infection) induced only a modest reduction in the frequency of infected cells. Quantification of HIV DNA in memory CD4
Identifiants
pubmed: 32132218
pii: 12/533/eaav3491
doi: 10.1126/scitranslmed.aav3491
pmc: PMC7293182
mid: NIHMS1589647
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI108433
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125127
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS061696
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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