Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML.
adipocyte
bone marrow microenvironment
fatty acid metabolism
fatty acid oxidation
therapy resistance
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
11
2019
accepted:
29
01
2020
entrez:
6
3
2020
pubmed:
7
3
2020
medline:
7
3
2020
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) cells modulate their metabolic state continuously as a result of bone marrow (BM) microenvironment stimuli and/or nutrient availability. Adipocytes are prevalent in the BM stroma and increase in number with age. AML in elderly patients induces remodeling and lipolysis of BM adipocytes, which may promote AML cell survival through metabolic activation of fatty acid oxidation (FAO). FAO reactions generate acetyl-CoA from fatty acids under aerobic conditions and, under certain conditions, it can cause uncoupling of mitochondrial oxidative phosphorylation. Recent experimental evidence indicates that FAO is associated with quiescence and drug-resistance in leukemia stem cells. In this review, we highlight recent progress in our understanding of fatty acid metabolism in AML cells in the adipocyte-rich BM microenvironment, and discuss the therapeutic potential of combinatorial regimens with various FAO inhibitors, which target metabolic vulnerabilities of BM-resident, chemoresistant leukemia cells.
Identifiants
pubmed: 32133293
doi: 10.3389/fonc.2020.00155
pmc: PMC7040225
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
155Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
Copyright © 2020 Tabe, Konopleva and Andreeff.
Références
Leukemia. 2016 Jan;30(1):209-18
pubmed: 26239197
BJU Int. 2003 May;91(7):716-20
pubmed: 12699491
Clin Sci (Lond). 2007 Aug;113(4):205-12
pubmed: 17319797
Br J Cancer. 2016 Jun 14;114(12):1305-12
pubmed: 27219018
Nat Med. 2002 Nov;8(11):1288-95
pubmed: 12368907
Blood. 2015 Oct 15;126(16):1925-9
pubmed: 26276667
Cell Stem Cell. 2013 Mar 7;12(3):329-41
pubmed: 23333149
Genes Dev. 2011 May 15;25(10):1041-51
pubmed: 21576264
Biochim Biophys Acta. 2011 Jun;1807(6):726-34
pubmed: 21692241
Cancer Cell. 2019 Feb 11;35(2):333-335
pubmed: 30753831
Cancer Cell. 2010 Apr 13;17(4):348-61
pubmed: 20385360
Nat Rev Mol Cell Biol. 2015 Jul;16(7):393-405
pubmed: 26122615
Blood. 2013 Aug 8;122(6):969-80
pubmed: 23814018
Front Oncol. 2013 Apr 02;3:67
pubmed: 23565503
Cell Signal. 2006 Apr;18(4):401-8
pubmed: 16182514
Nat Rev Cancer. 2016 Nov;16(11):732-749
pubmed: 27658529
Nature. 2010 Apr 29;464(7293):1313-9
pubmed: 20357764
Cell Stem Cell. 2016 Jul 7;19(1):23-37
pubmed: 27374788
Oncotarget. 2013 Nov;4(11):2108-23
pubmed: 24240026
Cell. 2010 Apr 2;141(1):69-80
pubmed: 20371346
J Biol Chem. 2003 Dec 5;278(49):48617-26
pubmed: 12970365
Cancer Lett. 2016 Feb 1;371(1):1-11
pubmed: 26607903
Mol Cell. 2008 Apr 25;30(2):214-26
pubmed: 18439900
Cancer Discov. 2015 Oct;5(10):1024-39
pubmed: 26382145
Cancer Discov. 2017 Jul;7(7):716-735
pubmed: 28416471
J Mol Cell Cardiol. 2013 Feb;55:27-30
pubmed: 23277191
Nat Med. 2011 Oct 30;17(11):1498-503
pubmed: 22037646
Leuk Lymphoma. 2017 Apr;58(4):986-988
pubmed: 27558298
Cancer Res. 2009 Oct 1;69(19):7867-74
pubmed: 19773440
J Biol Chem. 2012 Jul 13;287(29):24784-94
pubmed: 22619174
Haematologica. 2014 Jul;99(7):1124-7
pubmed: 24986872
Oncogenesis. 2016 Jan 25;5:e189
pubmed: 26807644
Yonsei Med J. 2016 Jul;57(4):865-71
pubmed: 27189278
Leukemia. 2014 Oct;28(10):2080-9
pubmed: 24646889
Antioxid Redox Signal. 2010 Sep 15;13(6):807-19
pubmed: 20367277
Nature. 2012 May 09;485(7400):661-5
pubmed: 22660331
Cell Metab. 2014 Aug 5;20(2):368-375
pubmed: 24998914
Cell Metab. 2015 Jun 2;21(6):805-21
pubmed: 26039447
PLoS Biol. 2018 Mar 29;16(3):e2003782
pubmed: 29596410
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Cell Metab. 2018 Jun 05;27(6):1357
pubmed: 29874570
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5
pubmed: 21498687
Cancer Res. 2015 Jun 15;75(12):2478-88
pubmed: 26077472
Nat Struct Mol Biol. 2008 Sep;15(9):924-31
pubmed: 19172745
Nat Rev Cancer. 2013 Apr;13(4):227-32
pubmed: 23446547
Cancer Res. 2011 Apr 1;71(7):2455-65
pubmed: 21459803
Cell Death Dis. 2016 May 19;7:e2226
pubmed: 27195673
Free Radic Biol Med. 2012 Jan 15;52(2):410-9
pubmed: 22115789
J Clin Invest. 1995 Sep;96(3):1382-8
pubmed: 7544802
Cancer Sci. 2019 Feb;110(2):751-760
pubmed: 30548479
Mol Cell Biochem. 2009 Jun;326(1-2):15-21
pubmed: 19116774
Mol Cell Biochem. 2002 Oct;239(1-2):213-9
pubmed: 12479588
Nature. 2017 Jan 5;541(7635):41-45
pubmed: 27974793
Nat Cell Biol. 2015 Apr;17(4):351-9
pubmed: 25774832
J Clin Invest. 2010 Jan;120(1):142-56
pubmed: 20038799
Blood. 2009 Feb 12;113(7):1504-12
pubmed: 18957686
Biogerontology. 2001;2(3):165-71
pubmed: 11708718
Annu Rev Cell Dev Biol. 2007;23:675-99
pubmed: 17645413
Blood. 2017 Mar 9;129(10):1320-1332
pubmed: 28049638
Exp Cell Res. 2001 Jan 15;262(2):170-9
pubmed: 11139341
Genes Dev. 2009 Mar 1;23(5):537-48
pubmed: 19270154
Mol Cell Biol. 2012 Jan;32(1):2-11
pubmed: 22025673
Obes Rev. 2010 May;11(5):380-8
pubmed: 19694967
Sci Rep. 2018 Nov 15;8(1):16837
pubmed: 30442990
Cancer Res. 2017 Mar 15;77(6):1453-1464
pubmed: 28108519