Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium.
Administration, Inhalation
Administration, Intravenous
Anesthetics, Inhalation
/ administration & dosage
Animals
Biological Transport
Brain
Caudate Nucleus
/ metabolism
Dexmedetomidine
/ administration & dosage
Drainage
Extracellular Fluid
/ drug effects
Extracellular Space
/ drug effects
Humans
Hypnotics and Sedatives
/ administration & dosage
Imidazoles
/ administration & dosage
Isoflurane
/ administration & dosage
Male
Norepinephrine
/ metabolism
Pentobarbital
/ administration & dosage
Prazosin
/ administration & dosage
Propranolol
/ administration & dosage
Rats, Sprague-Dawley
Thalamus
/ metabolism
deep brain extracellular space
dexmedetomidine
interstitial fluid
isoflurane
norepinephrine
pentobarbital sodium
Journal
Science China. Life sciences
ISSN: 1869-1889
Titre abrégé: Sci China Life Sci
Pays: China
ID NLM: 101529880
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
20
11
2019
accepted:
06
02
2020
pubmed:
7
3
2020
medline:
3
11
2020
entrez:
6
3
2020
Statut:
ppublish
Résumé
Brain interstitial fluid drainage and extracellular space are closely related to waste clearance from the brain. Different anesthetics may cause different changes of brain interstitial fluid drainage and extracellular space but these still remain unknown. Herein, effects of the inhalational isoflurane, intravenous sedative dexmedetomidine and pentobarbital sodium on deep brain matters' interstitial fluid drainage and extracellular space and underlying mechanisms were investigated. When compared to intravenous anesthetic dexmedetomidine or pentobarbital sodium, inhalational isoflurane induced a restricted diffusion of extracellular space, a decreased extracellular space volume fraction, and an increased norepinephrine level in the caudate nucleus or thalamus with the slowdown of brain interstitial fluid drainage. A local administration of norepinephrine receptor antagonists, propranolol, atipamezole and prazosin into extracellular space increased diffusion of extracellular space and interstitial fluid drainage whilst norepinephrine decreased diffusion of extracellular space and interstitial fluid drainage. These findings suggested that restricted diffusion in brain extracellular space can cause slowdown of interstitial fluid drainage, which may contribute to the neurotoxicity following the waste accumulation in extracellular space under inhaled anesthesia per se.
Identifiants
pubmed: 32133594
doi: 10.1007/s11427-019-1633-3
pii: 10.1007/s11427-019-1633-3
doi:
Substances chimiques
Anesthetics, Inhalation
0
Hypnotics and Sedatives
0
Imidazoles
0
atipamezole
03N9U5JAF6
Dexmedetomidine
67VB76HONO
Propranolol
9Y8NXQ24VQ
Isoflurane
CYS9AKD70P
Pentobarbital
I4744080IR
Norepinephrine
X4W3ENH1CV
Prazosin
XM03YJ541D
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1363-1379Références
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