Role of interleukin-4 in pathogenesis of oral lichen planus: A systematic review.
Journal
Medicina oral, patologia oral y cirugia bucal
ISSN: 1698-6946
Titre abrégé: Med Oral Patol Oral Cir Bucal
Pays: Spain
ID NLM: 101231694
Informations de publication
Date de publication:
01 May 2020
01 May 2020
Historique:
received:
24
09
2019
accepted:
11
11
2019
pubmed:
7
3
2020
medline:
15
4
2020
entrez:
6
3
2020
Statut:
epublish
Résumé
Oral lichen planus (OLP) is a premalignant mucocutaneous disease that affects 1-2% of the adult population. Immunological factor may act as etiological factor. The cellular immune cells such as T cells are important in pathogenesis of OLP. Interleukin-4 (IL-4) is secreted by T-helper 2 (Th2). Several studies have been carried out on the role of IL-4 in OLP. The aim of this study was to review the level of IL-4 in OLP, effective factors in the production of IL-4 and its role in the development of OLP. A search in PubMed was performed on the literature published from 2000 until august 2019 using the following keywords: "oral lichen planus" or "OLP" and "interleukin-4" or "IL-4". Originally, 37 articles were considered, of which 28 case-control articles were selected according to the inclusion/exclusion criteria. This review study shows that IL-4 plays a key role in the development of OLP. According to the past studies, there are several factors contributing to the production of this cytokine. Identification of the routes of production of IL-4 and its role in OLP might be useful for development of new preventive and therapeutic methods in management of patients with OLP.
Sections du résumé
BACKGROUND
BACKGROUND
Oral lichen planus (OLP) is a premalignant mucocutaneous disease that affects 1-2% of the adult population. Immunological factor may act as etiological factor. The cellular immune cells such as T cells are important in pathogenesis of OLP. Interleukin-4 (IL-4) is secreted by T-helper 2 (Th2). Several studies have been carried out on the role of IL-4 in OLP. The aim of this study was to review the level of IL-4 in OLP, effective factors in the production of IL-4 and its role in the development of OLP.
MATERIAL AND METHODS
METHODS
A search in PubMed was performed on the literature published from 2000 until august 2019 using the following keywords: "oral lichen planus" or "OLP" and "interleukin-4" or "IL-4".
RESULTS
RESULTS
Originally, 37 articles were considered, of which 28 case-control articles were selected according to the inclusion/exclusion criteria.
CONCLUSIONS
CONCLUSIONS
This review study shows that IL-4 plays a key role in the development of OLP. According to the past studies, there are several factors contributing to the production of this cytokine. Identification of the routes of production of IL-4 and its role in OLP might be useful for development of new preventive and therapeutic methods in management of patients with OLP.
Identifiants
pubmed: 32134902
pii: 23460
doi: 10.4317/medoral.23460
pmc: PMC7211366
doi:
Substances chimiques
Cytokines
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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