Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving.
Adolescent
Adult
Canada
/ epidemiology
Conditioning, Psychological
Craving
/ physiology
Cues
Female
Humans
Male
Middle Aged
Motivation
Polymorphism, Genetic
Receptors, Dopamine D3
/ genetics
Reinforcement, Psychology
Smoking
/ epidemiology
Smoking Cessation
/ statistics & numerical data
Tobacco Use Disorder
/ genetics
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 03 2020
05 03 2020
Historique:
received:
20
06
2019
accepted:
10
02
2020
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
24
11
2020
Statut:
epublish
Résumé
Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study investigated the relationship between the Ser9Gly variant and measures of both nicotine reinforcement and cue-elicited craving. Phenotypes of smoking behaviors were assessed in genetically grouped (Glycine vs. No Glycine carriers) current smokers (n = 104, ≥ 10 cigarettes per day). Laboratory measures included a forced choice session (to measure reinforcement of nicotine containing vs. denicotinized cigarettes), and a cue-reactivity session (to measure smoking cues vs. neutral cues elicited craving). The forced choice procedure revealed that subjective ratings were significantly higher in response to nicotinized compared to denicotinized cigarettes; however the Ser9Gly variant did not influence this effect. By comparison, smoking cues elicited greater craving over time compared to neutral cues, and Glycine carriers of the Ser9Gly D3R variant seem to experience a significant blunted cue-elicited craving effect. Results support D3R involvement in nicotine cue reactivity. However, more research is needed to reveal how this gene variant modulates various aspects of nicotine dependence.
Identifiants
pubmed: 32139730
doi: 10.1038/s41598-020-60940-4
pii: 10.1038/s41598-020-60940-4
pmc: PMC7058013
doi:
Substances chimiques
Receptors, Dopamine D3
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4085Références
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