Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During
Animals
Cytokines
/ biosynthesis
Genetic Engineering
/ methods
Genetic Therapy
Graft Survival
Kidney
/ metabolism
Kidney Transplantation
/ methods
Major Histocompatibility Complex
/ physiology
Male
Nuclear Proteins
/ genetics
Perfusion
Rats
Rats, Inbred Lew
Trans-Activators
/ genetics
beta 2-Microglobulin
/ genetics
HLA
gene therapy
lentiviral vector
organ engineering
organ perfusion
transplantation - kidney
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
09
2019
accepted:
31
01
2020
entrez:
7
3
2020
pubmed:
7
3
2020
medline:
26
3
2021
Statut:
epublish
Résumé
Organ gene therapy represents a promising tool to correct diseases or improve graft survival after transplantation. Polymorphic variation of the major histocompatibility complex (MHC) antigens remains a major obstacle to long-term graft survival after transplantation. Previously, we demonstrated that MHC-silenced cells are protected against allogeneic immune responses. We also showed the feasibility to silence MHC in the lung. Here, we aimed at the genetic engineering of the kidney toward permanent silencing of MHC antigens in a rat model. We constructed a sub-normothermic
Identifiants
pubmed: 32140158
doi: 10.3389/fimmu.2020.00265
pmc: PMC7042208
doi:
Substances chimiques
Cytokines
0
MHC class II transactivator protein
0
Nuclear Proteins
0
Trans-Activators
0
beta 2-Microglobulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
265Informations de copyright
Copyright © 2020 Yuzefovych, Valdivia, Rong, Hack, Rother, Schmitz, Bräsen, Wedekind, Moers, Wenzel, Gueler, Blasczyk and Figueiredo.
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