Lack of Asymmetry of Nigrostriatal Dopaminergic Function in Healthy Subjects.
Parkinson's disease
handedness
isolated rapid eye movement (REM) sleep behavior disorder
nigrostriatal dopaminergic system
symmetry
Journal
Movement disorders : official journal of the Movement Disorder Society
ISSN: 1531-8257
Titre abrégé: Mov Disord
Pays: United States
ID NLM: 8610688
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
19
12
2019
revised:
07
02
2020
accepted:
10
02
2020
pubmed:
7
3
2020
medline:
28
4
2021
entrez:
7
3
2020
Statut:
ppublish
Résumé
In right-handed patients with Parkinson's disease (PD) or isolated rapid eye movement sleep behavior disorder, dopamine transporter (DAT) [(123)I]β-carboxymethyoxy-3-β-(4-iodophenyl) tropane single photon emission computed tomography (SPECT) shows predominant nigrostriatal deficit in the left striatum. This suggests that in PD patients, the nigrostriatal system of the dominant hemisphere is more susceptible to disease-related dysfunction. To confirm this hypothesis, we investigated whether the nigrostriatal function is symmetric in healthy controls and in patients with PD. In 113 right-handed healthy controls and 279 right-handed early-PD patients, we examined the striatal dopaminergic terminals function in each hemisphere using DAT-SPECT. In the controls, DAT-SPECT showed symmetric specific binding ratios in the putamen and caudate nucleus of each hemisphere. In patients with PD, the specific binding ratio was lower in the left than in the right putamen. Right-handed healthy controls have symmetric nigrostriatal dopaminergic function. The left hemispheric predominance of nigrostriatal deficit seen in right-handed premotor and manifest PD represents an early pathological feature of the disease. © 2020 International Parkinson and Movement Disorder Society.
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1072-1076Informations de copyright
© 2020 International Parkinson and Movement Disorder Society.
Références
Pagano G, Ferrara N, Brooks DJ, Pavese N. Age of onset and Parkinson disease phenotype. Neurology 2016;86:1400-1407.
Lee CS, Schulzer M, Mak E, Hammerstad JP, Calne S, Calne DB. Patterns of asymmetry do not change over the course of idiopathic parkinsonism: implications for pathogenesis. Neurology 1995;45:435-439.
Cubo E, Martín PM, Martin-Gonzalez JA, Rodríguez-Blázquez C, Kulisevsky J, ELEP Group Members. Motor laterality asymmetry and nonmotor symptoms in Parkinson's disease. Mov Disord 2010;25:70-75.
Riederer P, Jellinger KA, Kolber P, Hipp G, Sian-Hülsmann J, Krüger R. Lateralisation in Parkinson disease. Cell Tissue Res 2018;373:297-312.
Djaldetti R, Ziv I, Melamed E. The mystery of motor asymmetry in Parkinson's disease. Lancet Neurol 2006;5:796-802.
Melamed E, Poewe W. Taking sides: is handedness involved in motor asymmetry of Parkinson's disease? Mov Disord 2012;27:171-173.
Van der Hoorn A, Burger H, Leenders KL, de Jong BM. Handedness correlates with the dominant Parkinson side: a systematic review and meta-analysis. Mov Disord 2012;27:206-210.
Van der Hoorn A, Bartels AL, Leenders KL, de Jong BM. Handedness and dominant side of symptoms in Parkinson's disease. Parkinsonism Relat Disord 2011;17:58-60.
Uitti RJ, Baba Y, Whaley NR, Wszolek ZK, Putzke JD. Parkinson disease-handedness predicts asymmetry. Neurology 2005;64:1925-1930.
Barrett MJ, Wylie SA, Harrison MB, Wooten GF. Handedness and motor symptom asymmetry in Parkinson's disease. J Neurol Neurosurg Psychiatry 2011;82:1122-1124.
Yust-Katz S, Tesler D, Treves TA, Melamed E, Djaldetti R. Handedness as a predictor of side of onset of Parkinson's disease. Parkinsonism Relat Disord 2008;14:633-635.
Prasad S, Saini J, Yadav R, Pal PK. Motor asymmetry and neuromelanin imaging: concordance in Parkinson's disease. Parkinsonism Relat Disord 2018;53:28-32.
Marek KL, Seibyl JP, Zoghbi SS, et al. [123I]beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease. Neurology 1996;46:231-237.
Catafau AM, Tolosa E, DaTSCAN Clinically Uncertain Parkinsonian Syndromes Study Group. Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes. Mov Disord 2004;1:1175-1182.
Scherfler C, Seppi K, Mair KJ, et al. Left hemispheric predominance of nigrostriatal dysfunction in Parkinson's disease. Brain 2012;135:3348-3354.
Iranzo A, Tolosa E, Gelpi E, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behavior disorder: an observational cohort study. Lancet Neurol 2013;12:443-453.
Högl B, Stefani A, Videnovic A. Idiopathic REM sleep behaviour disorder and neurodegeneration-an update. Nat Rev Neurol 2018;14:40-55.
Iranzo A, Stefani A, Niñerola A, et al. Left hemispheric predominance of nigrostriatal deficit in isolated REM sleep behaviour disorder. Neurology 2019 (in press).
Marek K, Jennings D, Lasch S, et al. The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 2011;95:629-635.
Marek K, Chowdhury S, Siderowf A, et al. The Parkinson's Progression Markers Initiative (PPMI)-establishing a PD biomarker cohort. Ann Clin Transl Neurol 2018;5:1460-1477.
Olfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 1971;9:97-113.