Arterial baroreflex regulation of muscle sympathetic single-unit activity in men: influence of resting blood pressure.
arterial baroreflex
hypertension
microneurography
sympathetic nervous system
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
7
3
2020
medline:
26
5
2020
entrez:
7
3
2020
Statut:
ppublish
Résumé
The arterial baroreflex has dominant control over multiunit muscle sympathetic nerve activity (MSNA) burst occurrence, but whether this extends to all single units or is influenced by resting blood pressure status is unclear. In 22 men (32 ± 8 yr), we assessed 68 MSNA single units during sequential bolus injections of nitroprusside and phenylephrine (modified Oxford). Sympathetic baroreflex sensitivity (sBRS) was quantified as the weighted negative linear regression slope between diastolic blood pressure (DBP) and single-unit spike firing probability and multiple spike firing. Strong negative linear relationships (
Identifiants
pubmed: 32142360
doi: 10.1152/ajpheart.00700.2019
doi:
Substances chimiques
Vasodilator Agents
0
Nitroprusside
169D1260KM
Phenylephrine
1WS297W6MV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM