Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin-5, and Interleukin-21.
asthma
ghrelin
interleukin-21 (IL-21), obesity
interleukin-4 (IL-4)
interleukin-5 (IL-5)
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
04 03 2020
04 03 2020
Historique:
received:
28
01
2020
revised:
26
02
2020
accepted:
02
03
2020
entrez:
8
3
2020
pubmed:
8
3
2020
medline:
10
10
2020
Statut:
epublish
Résumé
Ghrelin is a peptide hormone with direct or indirect effects on obesity and asthma. More data are required to understand the effect of ghrelin on the control and pathogenesis of these diseases. The aim of this study was to evaluate ghrelin levels in selected groups of children to identify the association between serum ghrelin, obesity, and the severity of asthma. The study included 401 school children selected from the Najran area and grouped into non-obese asthmatics, obese asthmatics, obese non-asthmatics and controls (non-obese non-asthmatics). Blood levels of ghrelin, interleukin (IL)-4, IL-5 and IL-21 were determined by ELISA. The mean ghrelin values were insignificantly increased in obese children compared with non-obese children. The highest blood ghrelin values were in the non-obese asthmatic group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in asthmatic children compared with non-asthmatic children (
Identifiants
pubmed: 32143340
pii: ijerph17051656
doi: 10.3390/ijerph17051656
pmc: PMC7084446
pii:
doi:
Substances chimiques
Ghrelin
0
Interleukin-5
0
Interleukins
0
Interleukin-4
207137-56-2
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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