Effects of six months of aerobic and resistance training on metabolic markers and bone mineral density in older men on androgen deprivation therapy for prostate cancer.

Aged Androgen Antagonists / therapeutic use Androgens Bone Density Humans Male Prostatic Neoplasms / drug therapy Resistance Training
Androgen deprivation therapy Bone mineral density Exercise Metabolic biomarkers Prostate cancer

Journal

Journal of geriatric oncology
ISSN: 1879-4076
Titre abrégé: J Geriatr Oncol
Pays: Netherlands
ID NLM: 101534770

Informations de publication

Date de publication:
09 2020
Historique:
received: 12 08 2019
revised: 22 12 2019
accepted: 26 02 2020
pubmed: 8 3 2020
medline: 29 7 2021
entrez: 8 3 2020
Statut: ppublish

Résumé

Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with metabolic perturbations and declines in bone mineral density (BMD). Exercise interventions provide multiple health benefits to older men on ADT; however, their effect on metabolic biomarkers and BMD remains unclear. A secondary analysis of a phase II randomized controlled trial was conducted to assess the effect of a six-month moderate-intensity aerobic and resistance exercise program on metabolic biomarkers and BMD in men on ADT. Participants were randomized to three different exercise delivery models: personal training; supervised group exercise; or home-based exercise. Analysis of metabolic biomarkers (lipid profile and glucose) was conducted at baseline, six and twelve months. BMD of the lumbar spine, femoral neck and hip were assessed at baseline and twelve months. Both within- and between-group analyses of change scores adjusted for baseline values were performed. Forty-eight men (mean age 69.8y) were enrolled. Baseline values of metabolic biomarkers and BMD were comparable between groups and the three groups were combined for the primary analysis. At six months, no changes in metabolic biomarkers were found; however, at twelve months low-density lipoprotein (+0.28 mmol/L; 95%CI, 0.04 to 0.51) and total cholesterol (+0.31 mmol/L; 95%CI, 0.00 to 0.61) were significantly increased from baseline. No changes were found in BMD. In a secondary between-group analysis, no improvements were observed for any metabolic biomarker or BMD measurement. Different exercise prescription parameters (modality and intensity) or combined diet/exercise interventions may be needed to foster favorable metabolic and skeletal adaptations during ADT.

Sections du résumé

BACKGROUND
Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with metabolic perturbations and declines in bone mineral density (BMD). Exercise interventions provide multiple health benefits to older men on ADT; however, their effect on metabolic biomarkers and BMD remains unclear.
METHODS
A secondary analysis of a phase II randomized controlled trial was conducted to assess the effect of a six-month moderate-intensity aerobic and resistance exercise program on metabolic biomarkers and BMD in men on ADT. Participants were randomized to three different exercise delivery models: personal training; supervised group exercise; or home-based exercise. Analysis of metabolic biomarkers (lipid profile and glucose) was conducted at baseline, six and twelve months. BMD of the lumbar spine, femoral neck and hip were assessed at baseline and twelve months. Both within- and between-group analyses of change scores adjusted for baseline values were performed.
RESULTS
Forty-eight men (mean age 69.8y) were enrolled. Baseline values of metabolic biomarkers and BMD were comparable between groups and the three groups were combined for the primary analysis. At six months, no changes in metabolic biomarkers were found; however, at twelve months low-density lipoprotein (+0.28 mmol/L; 95%CI, 0.04 to 0.51) and total cholesterol (+0.31 mmol/L; 95%CI, 0.00 to 0.61) were significantly increased from baseline. No changes were found in BMD. In a secondary between-group analysis, no improvements were observed for any metabolic biomarker or BMD measurement.
CONCLUSIONS
Different exercise prescription parameters (modality and intensity) or combined diet/exercise interventions may be needed to foster favorable metabolic and skeletal adaptations during ADT.

Identifiants

DOI: 10.1016/j.jgo.2020.02.013 PMID: 32143995
pubmed: 32143995
pii: S1879-4068(19)30378-9
doi: 10.1016/j.jgo.2020.02.013
pii:
doi:

Substances chimiques

Androgen Antagonists 0
Androgens 0

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1074-1077

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors have no conflicts of interest to disclose.

Auteurs

Efthymios Papadopoulos (E)

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada; Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada. Electronic address: efthymios.papadopoulos@mail.utoronto.ca.

Daniel Santa Mina (DS)

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada; Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.

Nicole Culos-Reed (N)

Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada.

Sara Durbano (S)

Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.

Paul Ritvo (P)

York University, Toronto, ON M3J 1P3, Canada.

Catherine M Sabiston (CM)

Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON M5S 2W6, Canada.

Murray Krahn (M)

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada.

George Tomlinson (G)

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada.

Meagan O'Neill (M)

Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.

Amna Iqbal (A)

Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada.

Narhari Timilshina (N)

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada.

Andrew Matthew (A)

Cancer Clinical Research Unit, University Health Network, Toronto, ON M5G 2C1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada.

Padraig Warde (P)

Cancer Clinical Research Unit, University Health Network, Toronto, ON M5G 2C1, Canada.

Shabbir M H Alibhai (SMH)

Department of Supportive Care, University Health Network, Toronto, ON M5G 2C4, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto ON M5S 1A1, Canada; Faculty of Medicine, University of Toronto, Toronto ON M5S 1A8, Canada.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Effects of six months of aerobic and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Antihormones › Antagonistes des androgènes › Effects of six months of aerobic and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Effects of six months of aerobic and...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Densité osseuse › Effects of six months of aerobic and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effects of six months of aerobic and...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Effects of six months of aerobic and...
questionsmedicales.fr › Activités humaines › Exercice physique › Mise en condition physique de l'homme › Entraînement en résistance › Effects of six months of aerobic and...