Quantitative MRI Reveals Microstructural Changes in the Upper Leg Muscles After Running a Marathon.
DTI
inflammation
microstructure
muscle injury
perfusion
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
10
09
2019
revised:
13
02
2020
accepted:
13
02
2020
pubmed:
8
3
2020
medline:
15
5
2021
entrez:
8
3
2020
Statut:
ppublish
Résumé
The majority of sports-related injuries involve skeletal muscle. Unlike acute trauma, which is often caused by a single traumatic event leading to acute symptoms, exercise-induced microtrauma may remain subclinical and difficult to detect. Therefore, novel methods to detect and localize subclinical exercise-induced muscle microtrauma are desirable. To assess acute and delayed microstructural changes in upper leg muscles with multiparametric quantitative MRI after running a marathon. Longitudinal; 1-week prior, 24-48 hours postmarathon and 2-week follow-up POPULATION: Eleven men participants (age: 47-68 years). Spin-echo echo planar imaging (SE-EPI) with diffusion weighting, multispin echo, Dixon, and fat-suppressed turbo spin-echo (TSE) sequences at 3T. MR datasets and creatine kinase (CK) concentrations were obtained at three timepoints. Diffusion parameters, perfusion fractions, and quantitative (q)T Differences between timepoints in MR parameters were assessed with a multilevel linear mixed model and in CK concentrations with a Friedman test. Mean diffusivity (MD) and qT CK concentrations were elevated (1194 U/L [166-3906], P < 0.001) at 24-48 hours postmarathon and returned to premarathon values (323 U/L [56-2216]) at 2-week follow-up. Most of the MRI diffusion indices in muscles without acute injury changed at 24-48 hours postmarathon and returned to premarathon values at follow-up (MD, RD, and λ3; P < 0.006). qT Marathon running-induced microtrauma was detected with MRI in individual whole upper leg muscles and even more pronounced on local segments. 2 TECHNICAL EFFICACY STAGE: 3 J. Magn. Reson. Imaging 2020;52:407-417.
Sections du résumé
BACKGROUND
The majority of sports-related injuries involve skeletal muscle. Unlike acute trauma, which is often caused by a single traumatic event leading to acute symptoms, exercise-induced microtrauma may remain subclinical and difficult to detect. Therefore, novel methods to detect and localize subclinical exercise-induced muscle microtrauma are desirable.
PURPOSE
To assess acute and delayed microstructural changes in upper leg muscles with multiparametric quantitative MRI after running a marathon.
STUDY TYPE
Longitudinal; 1-week prior, 24-48 hours postmarathon and 2-week follow-up POPULATION: Eleven men participants (age: 47-68 years).
FIELD STRENGTH/SEQUENCE
Spin-echo echo planar imaging (SE-EPI) with diffusion weighting, multispin echo, Dixon, and fat-suppressed turbo spin-echo (TSE) sequences at 3T. MR datasets and creatine kinase (CK) concentrations were obtained at three timepoints.
ASSESSMENT
Diffusion parameters, perfusion fractions, and quantitative (q)T
STATISTICAL TESTS
Differences between timepoints in MR parameters were assessed with a multilevel linear mixed model and in CK concentrations with a Friedman test. Mean diffusivity (MD) and qT
RESULTS
CK concentrations were elevated (1194 U/L [166-3906], P < 0.001) at 24-48 hours postmarathon and returned to premarathon values (323 U/L [56-2216]) at 2-week follow-up. Most of the MRI diffusion indices in muscles without acute injury changed at 24-48 hours postmarathon and returned to premarathon values at follow-up (MD, RD, and λ3; P < 0.006). qT
DATA CONCLUSION
Marathon running-induced microtrauma was detected with MRI in individual whole upper leg muscles and even more pronounced on local segments.
LEVEL OF EVIDENCE
2 TECHNICAL EFFICACY STAGE: 3 J. Magn. Reson. Imaging 2020;52:407-417.
Identifiants
pubmed: 32144857
doi: 10.1002/jmri.27106
pmc: PMC7496541
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-417Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
Références
J Appl Physiol (1985). 2009 Oct;107(4):1276-84
pubmed: 19608924
J Magn Reson Imaging. 2006 Aug;24(2):402-8
pubmed: 16823776
Radiology. 1986 Nov;161(2):401-7
pubmed: 3763909
J Magn Reson Imaging. 2011 Oct;34(4):887-94
pubmed: 21769968
Br J Sports Med. 2016 Feb;50(4):205-8
pubmed: 26519522
Eur Radiol. 2020 May;30(5):2830-2842
pubmed: 31953666
Radiology. 2015 Feb;274(2):548-62
pubmed: 25279435
J Physiol. 2018 Apr 15;596(8):1467-1483
pubmed: 29455454
Radiology. 2015 May;275(2):570-8
pubmed: 25575118
Neuromuscul Disord. 2017 May;27(5):458-464
pubmed: 28302391
Magn Reson Med. 2017 Jul;78(1):233-246
pubmed: 27538923
Phys Med Biol. 2015 Nov 7;60(21):R297-322
pubmed: 26448064
J Appl Physiol (1985). 2002 Nov;93(5):1716-22
pubmed: 12381759
NMR Biomed. 2016 Apr;29(4):431-43
pubmed: 26814454
MAGMA. 2018 Oct;31(5):599-608
pubmed: 29761414
Magn Reson Med. 2008 Oct;60(4):934-44
pubmed: 18816814
Scand J Med Sci Sports. 2015 Feb;25(1):e28-39
pubmed: 24738493
Eur J Appl Physiol. 2007 Dec;101(6):713-20
pubmed: 17724609
NMR Biomed. 2019 Sep;32(9):e4119
pubmed: 31313867
Invest Radiol. 2019 Jan;54(1):48-54
pubmed: 30157100
NMR Biomed. 2019 May;32(5):e4072
pubmed: 30861224
Springerplus. 2016 Apr 12;5:441
pubmed: 27104129
Eur J Appl Physiol Occup Physiol. 1994;69(5):408-13
pubmed: 7875137
J Orthop Sports Phys Ther. 2010 Feb;40(2):67-81
pubmed: 20118524
J Appl Physiol (1985). 2008 Sep;105(3):958-63
pubmed: 18599678
NMR Biomed. 2013 Nov;26(11):1339-52
pubmed: 23670990
Med Sci Sports Exerc. 1998 Feb;30(2):266-74
pubmed: 9502356
Scand J Med Sci Sports. 2018 Jan;28(1):95-106
pubmed: 28314055
J Nutr Metab. 2012;2012:960363
pubmed: 22288008
Br J Sports Med. 2013 Apr;47(6):342-50
pubmed: 23080315
Sports Med. 2015 Jan;45(1):133-46
pubmed: 25119158
Biophys J. 1974 Aug;14(8):583-606
pubmed: 4853385
Magn Reson Imaging. 1995;13(7):943-8
pubmed: 8583872
Invest Radiol. 2015 Jul;50(7):456-63
pubmed: 25811832
Radiology. 1991 Jun;179(3):659-64
pubmed: 2027970
Phys Ther. 1993 Dec;73(12):911-21
pubmed: 8248299
Sci Rep. 2017 Jul 18;7(1):5769
pubmed: 28720871
J Magn Reson Imaging. 2017 Oct;46(4):1137-1148
pubmed: 28152253
MAGMA. 2008 Jul;21(4):273-8
pubmed: 18633660
Am J Sports Med. 2011 Jun;39(6):1226-32
pubmed: 21335353
Med Sci Sports Exerc. 1984 Dec;16(6):529-38
pubmed: 6392811