Prior placental bed disorders and later dementia: a retrospective Swedish register-based cohort study.
Abortion, Spontaneous
/ epidemiology
Dementia
/ epidemiology
Female
Fetal Growth Retardation
/ epidemiology
Fetal Membranes, Premature Rupture
/ epidemiology
Humans
Placenta
/ blood supply
Placenta Diseases
/ epidemiology
Pre-Eclampsia
/ epidemiology
Pregnancy
Pregnancy Complications
/ epidemiology
Premature Birth
/ epidemiology
Proportional Hazards Models
Registries
Retrospective Studies
Risk Factors
Sweden
/ epidemiology
Alzheimer’s disease
dementia
placental atherosis
placental disease
vascular dementia
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
accepted:
25
02
2020
pubmed:
8
3
2020
medline:
27
10
2020
entrez:
8
3
2020
Statut:
ppublish
Résumé
To investigate the association between a history of placental bed disorders and later dementia. Retrospective population-based cohort study. Sweden. All women giving birth in Sweden between 1973 and 1993 (1 128 709). Women with and without placental bed disorders (hypertensive disorders of pregnancy including pre-eclampsia, fetal growth restriction, spontaneous preterm labour and birth, preterm premature rupture of membranes, abruptio placenta, late miscarriages) and other pregnancy complications were identified by means of the Swedish Medical Birth Register. International classification of disease was used. Data were linked to other National Registers. Participants were followed up until 2013. The Cox proportional hazards model was used to calculate hazard ratios for women with and without pregnancy complications and were adjusted for possible confounders. Diagnosis of vascular dementia and non-vascular dementia. Adjusted for cardiovascular disease and socio-demographic factors, an increased risk of vascular dementia was shown in women with previous pregnancy-induced hypertension (Hazard ratio [HR] 1.88, 95% CI 1.32-2.69), pre-eclampsia (HR 1.63, 95% CI 1.23-2.16), spontaneous preterm labour and birth (HR 1.65, 95% CI 1.12-2.42) or preterm premature rupture of membranes (HR 1.60, 95% CI 1.08-2.37). No statistically significant increased risk was seen for other pregnancy complications or non-vascular dementia even though many of the point estimates indicated increased risks. Women with placental bed disorders have a higher risk for vascular disease. Mechanisms behind the abnormal placentation remain elusive, although maternal constitutional factors, abnormal implantation as well as impaired angiogenesis have been suggested. Placental bed syndromes associated with vascular dementia even after adjusting for cardiovascular disease.
Identifiants
pubmed: 32145044
doi: 10.1111/1471-0528.16201
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1090-1099Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.
Références
Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 2007;335:974.
McDonald SD, Malinowski A, Zhou Q, Yusuf S, Devereaux PJ. Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses. Am Heart J 2008;156:918-30.
Brown MC, Best KE, Pearce MS, Waugh J, Robson SC, Bell R. Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis. Eur J Epidemiol 2013;28:1-19.
Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, et al. Preeclampsia and future cardiovascular. Health: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 2017;10:1-9.
de Bruijn RF, Ikram MA. Cardiovascular risk factors and future risk of Alzheimer's disease. BMC Med 2014;12:130.
Aukes AM, De Groot JC, Wiegman MJ, Aarnoudse JG, Sanwikarja GS, Zeeman GG. Long-term cerebral imaging after pre-eclampsia. BJOG 2012;119:1117-22.
Postma IR, Bouma A, Ankersmit IF, Zeeman GG. Neurocognitive functioning following preeclampsia and eclampsia: a long-term follow-up study. Am J Obstet Gynecol 2014;211:37.e1-e9.
Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9:689-701.
Jokinen H, Lipsanen J, Schmidt R, Fazekas F, Gouw AA, van der Flier WM, et al. Brain atrophy accelerates cognitive decline in cerebral small vessel disease: the LADIS study. Neurology 2012;78:1785-92.
Aukes AM, Wessel I, Dubois AM, Aarnoudse JG, Zeeman GG. Self-reported cognitive functioning in formerly eclamptic women. Am J Obstet Gynecol 2007;197:365.e1-e6.
Abheiden CN, van Doornik R, Aukes AM, van der Flier WM, Scheltens P, de Groot CJ. Hypertensive disorders of pregnancy appear not to be associated with Alzheimer's disease later in Life. Dement Geriatr Cogn Dis Extra 2015;5:375-85.
Nelander M, Cnattingius S, Akerud H, Wikstrom J, Pedersen NL, Wikstrom AK. Pregnancy hypertensive disease and risk of dementia and cardiovascular disease in women aged 65 years or older: a cohort study. BMJ Open 2016;6:e009880.
Theilen LH, Fraser A, Hollingshaus MS, Schliep KC, Varner MW, Smith KR, et al. All-cause and cause-specific mortality after hypertensive disease of pregnancy. Obstet Gynecol 2016;128:238-44.
Andolf EG, Sydsjo GC, Bladh MK, Berg G, Sharma S. Hypertensive disorders in pregnancy and later dementia: a Swedish National Register Study. Acta Obstet Gynecol Scand 2017;96:464-71.
Basit S, Wohlfahrt J, Boyd HA. Pre-eclampsia and risk of dementia later in life: nationwide cohort study. BMJ 2018;363:k4109.
Staff AC, Redman CW, Williams D, Leeson P, Moe K, Thilaganathan B, et al. Pregnancy and long-term maternal cardiovascular health: progress through harmonization of research cohorts and biobanks. Hypertension 2016;67:251-60.
Brossens I, Pijnenborg R, Vercruysse L, Romero R. The ‘Great Obstetrical Syndromes’ are associated with disorders of deep placentation. Am J Obstet Gynecol 2011;204:193-201.
National Board of Health and Welfare, Centre for Epidemiology. The Swedish Medical Birth Register; A summary of content and quality (Article no. 2003-112-3). Stockholm, Sweden. 2003 [accessed 11 September]. Available from: http://www.socialstyrelsen.se/Lists/Artikelkatalog/Attachments/10655/2003-112-3_20031123.pdf.
National Board of Health and Welfare, Centre for Epidemiology. Statistics - Health and Medical Care, Pregnancies, Deliveries and Newborn Infants, The Swedish Medical Birth Register 1973-2014, Assisted Reproduction, treatment 1991-2013 (Article No.2015-12-27) Stockholm, Sweden. 2015 [accessed 11 September]. Available from: http://www.socialstyrelsen.se/Lists/Artikelkatalog/Attachments/20009/2015-12-27.pdf.
Cnattingius S, Ericson A, Gunnarskog J, Kallen B. A quality study of a medical birth registry. Scand J Soc Med 1990;18:143-8.
National Board of Health and Welfare, Centre for Epidemiology. Kvalitet och innehåll i patientregistret- Utskrivningar från slutenvård 1964-2006 och besök i öppenvård (exklusive primärvårdsbesök) 1997-2006.Stockholm, Sweden. 2008 [accessed 11 September]. Available from: http://www.socialstyrelsen.se/Lists/Artikelkatalog/Attachments/8708/2008-125-120081251rev.pdf.
National Board of Health and Welfare, Centre for Epidemiology. Kodningskvalitet i patientregistret, Ett nytt verktyg för att mäta kvalitet. Stockholm, Sweden. 2013 [accessed 11 September]. Available from: https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/klassifikationer-och-koder/2013-3-10.pdf.
Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, et al. External review and validation of the Swedish national inpatient register. BMC Public Health 2011;11:450.
D’Amico M, Agozzino E, Biagino A, Simonetti A, Marinelli P. Ill-defined and multiple causes on death certificates: a study of misclassification in mortality statistics. Eur J Epidemiol 1999;15:141-8.
Johansson LA, Westerling R. Comparing Swedish hospital discharge records with death certificates: Implications for mortality statistics. Int J Epidemiol 2000;29:495-502.
National Board of Health and Welfare, Centre for Epidemiology. Causes of death 2008. Stockholm, Sweden: 2010 [accessed 11 September]. Available from: Retrieved from http://www.socialstyrelsen.se/Lists/Artikelkatalog/Attachments/18014/2010-4-31.pdf.
National Board of Health and Welfare, Centre for Epidemiology. Dödsorsaksstatistik Historik, produktionsmetoder och tillförlitlighet. Stockholm, Sweden: 2010. [accessed 11 September]. Available from: http://www.socialstyrelsen.se/Lists/Artikelkatalog/Attachments/18019/2010-4-33.pdf
Statistics Sweden. Multi-Generation Register 2016; a description of contents and quality. (Serial no. 2017:2.). Örebro, Sweden 2017 [accessed 11 September]. Available from: https://www.scb.se/contentassets/731ea818c63b406a928b9b824ad7f818/ov9999_2016a01_br_be96br1702.pdf
Statistics Sweden. Description of the Population in Sweden 2008. Örebro, Sweden. 2009 [accessed 11 September]. Available from: http://www.scb.se/statistik/_publikationer/BE0101_2008A01_BR_BE0109TEXT.pdf
Statistics Sweden. Educational attainment of the population 2018. (Publication no. UF 37 SM 1902). Örebro, Sweden. 2019 [accessed 11 September]. Available from: https://www.scb.se/contentassets/c4f928a71e934437b1320762371c35a1/uf0506_2018a01_sm_uf37sm1902.pdf
Statistics Sweden. Population and Housing Census 1970 (SOS). Part 12. Report on the planning and processing of the Population and Housing Census 1970. Stockholm, Sweden. 1974.
Statistics Sweden. Bortfallsanalys av Utbildningsregistret 2014, Temarapport 2017:5. Örebro, Sweden (2017: [accessed 11 September]. Available from: https://www.scb.se/contentassets/18f5f8f045b8409899fd6600485fa377/uf0506_2016a01_br_a40br1705.pdf
Kalaria RN. The pathology and pathophysiology of vascular dementia. Neuropharmacology 2018;134(Pt B):226-39.
Poggesi A, Pasi M, Pescini F, Pantoni L, Inzitari D. Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review. J Cereb Blood Flow Metab 2016;36:72-94.
Roberts JM, Lain KY. Recent Insights into the pathogenesis of pre-eclampsia. Placenta 2002;23:359-72.
Chen X, Scholl TO. Maternal biomarkers of endothelial dysfunction and preterm delivery. PLoS One 2014;9:e85716.
Ovayolu A, Ovayolu G, Karaman E, Yuce T, Turgut A, Bostancieri N. Maternal serum endocan concentrations are elevated in patients with preterm premature rupture of membranes. J Perinat Med 2019;47:510-5.
Ostlund E, Al-Nashi M, Hamad RR, Larsson A, Eriksson M, Bremme K, et al. Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by preeclampsia. Hypertens Res 2013;36:1081-7.
Smith GC, Crossley JA, Aitken DA, Jenkins N, Lyall F, Cameron AD, et al. Circulating angiogenic factors in early pregnancy and the risk of preeclampsia, intrauterine growth restriction, spontaneous preterm birth, and stillbirth. Obstet Gynecol 2007;109:1316-24.
Kim YM, Chaiworapongsa T, Gomez R, Bujold E, Yoon BH, Rotmensch S, et al. Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes. Am J Obstet Gynecol 2002;187:1137-42.
Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, et al. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2003;189:1063-9.
Kim YM, Chaemsaithong P, Romero R, Shaman M, Kim CJ, Kim JS, et al. The frequency of acute atherosis in normal pregnancy and preterm labor, preeclampsia, small-for-gestational age, fetal death and midtrimester spontaneous abortion. J Matern Fetal Neonatal Med 2015;28:2001-9.
Staff AC, Dechend R, Redman CW. Review: preeclampsia, acute atherosis of the spiral arteries and future cardiovascular disease: two new hypotheses. Placenta 2013;34(Suppl):S73-S78.