Ergosterol exerts a differential effect on AR-dependent LNCaP and AR-independent DU-145 cancer cells.
Androgen receptor
DU-145
LNCaP
MTT bioassay
ergosterol
molecular dynamics simulations
Journal
Natural product research
ISSN: 1478-6427
Titre abrégé: Nat Prod Res
Pays: England
ID NLM: 101167924
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
pubmed:
10
3
2020
medline:
24
11
2021
entrez:
10
3
2020
Statut:
ppublish
Résumé
Androgen-dependent LNCaP and androgen-independent DU-145 cells, were treated with different concentrations of ergosterol (15 µM and 25 µM) and its respective cell viability was measured by MTT bioassay. While ergosterol showed an antiproliferative effect on LNCaP, on DU-145 promoted cell proliferation. This differential effect suggests that the effect of ergosterol might be related to its ability to act as an Androgen Receptor ligand.
Identifiants
pubmed: 32146854
doi: 10.1080/14786419.2020.1737054
doi:
Substances chimiques
Androgens
0
Dihydrotestosterone
08J2K08A3Y
Ergosterol
Z30RAY509F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM