New Prospects for Molecular Targets for Chordomas.
Brachyury
Chordoma
Immunotherapy
Molecular targeted therapy
Notochord
Receptor tyrosine kinase (RTKs)
Journal
Neurosurgery clinics of North America
ISSN: 1558-1349
Titre abrégé: Neurosurg Clin N Am
Pays: United States
ID NLM: 9008004
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
entrez:
10
3
2020
pubmed:
10
3
2020
medline:
16
12
2020
Statut:
ppublish
Résumé
Chordomas are malignant, highly recurrent tumors of the midline skeleton that arise from the remnants of the notochord. The development of systemic therapy is critically important to ultimately managing this tumor. Several ongoing trials are attempting to use molecular targeted therapies for mutated pathways in recurrent and advanced chordomas and have shown promise. In addition, immunotherapies, including brachyury-directed vaccination and checkpoint inhibition, have also been attempted with encouraging results. This article discusses the major pathways that have been implicated in the pathogenesis of chordoma with an emphasis on molecular vulnerabilities that future therapies are attempting to exploit.
Identifiants
pubmed: 32147018
pii: S1042-3680(19)30098-1
doi: 10.1016/j.nec.2019.11.004
pmc: PMC7374924
mid: NIHMS1598411
pii:
doi:
Substances chimiques
Fetal Proteins
0
T-Box Domain Proteins
0
Brachyury protein
EQ43SC3GDB
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-300Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH120026
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure The authors have nothing to disclose.
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