The impact of aging on the subregions of the fusiform gyrus in healthy older adults.
MRI
age
brain
cytoarchitecture
fusiform gyrus
gender
gray matter
sex
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
18
10
2019
revised:
23
12
2019
accepted:
12
01
2020
pubmed:
10
3
2020
medline:
3
11
2021
entrez:
10
3
2020
Statut:
ppublish
Résumé
The fusiform gyrus is known to decrease in size with increasing age. However, reported findings are inconsistent and existing studies differ in terms of the cohorts examined and/or the methods applied. Here, we analyzed age-related links in four distinct subregions of the fusiform gyrus through integrating imaging-based intensity information with microscopically defined cytoarchitectonic probabilities. In addition to age effects we investigated sex effects as well as age-by-sex interactions in a relatively large sample of 468 healthy subjects (272 females/196 males) covering a broad age range (42-97 years). We observed significant negative correlations between age and all four subregions of the fusiform gyrus indicating volume decreases over time, albeit with subregion-specific trajectories. Additionally, we observed significant negative quadratic associations with age for some subregions, suggesting an accelerating volume loss over time. These findings may serve as a frame of reference for future cross-sectional as well as longitudinal studies, not only for normative samples but also potentially for clinical conditions that present with abnormal atrophy of the fusiform gyrus. We did not detect any significant sex differences or sex-by-age interactions, suggesting that the size of the fusiform gyrus is similar in male and female brains and that age-related atrophy follows a similar trajectory in both men and women.
Identifiants
pubmed: 32147882
doi: 10.1002/jnr.24586
pmc: PMC8505033
mid: NIHMS1549807
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
263-270Subventions
Organisme : NIA NIH HHS
ID : R01 AG043434
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB009352
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081720
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01HD081720
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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