68Ga-Prostate-Specific Membrane Antigen Uptake in a Pancreatic Neuroendocrine Tumor.
Artifacts
Biological Transport
Gallium Isotopes
Gallium Radioisotopes
Humans
Male
Membrane Glycoproteins
/ metabolism
Middle Aged
Neuroendocrine Tumors
/ diagnostic imaging
Organometallic Compounds
/ metabolism
Pancreatic Neoplasms
/ diagnostic imaging
Positron Emission Tomography Computed Tomography
Prostatectomy
Prostatic Neoplasms
/ diagnostic imaging
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
pubmed:
10
3
2020
medline:
28
8
2020
entrez:
10
3
2020
Statut:
ppublish
Résumé
We present a 60-year-old man with known prostate cancer treated with robot-assisted radical prostatectomy. Prostate-specific antigen levels did not decline accordingly, and a second Ga-PSMA PET/CT demonstrated a new focus with high Ga-PSMA uptake in the pancreatic tail. A subsequent CT scan did not display the lesion as a typical pancreatic tumor, and a spleen scintigraphy was also negative excluding an ectopic intrapancreatic accessory spleen. Ga-DOTATOC PET/CT showed uptake in the same area of the pancreatic tail consistent with a neuroendocrine tumor. This case illustrates that neuroendocrine tumors can be important pitfalls in Ga-PSMA PET/CT performed in prostate cancer patients.
Identifiants
pubmed: 32149792
doi: 10.1097/RLU.0000000000002997
pii: 00003072-202005000-00010
doi:
Substances chimiques
Gallium Isotopes
0
Gallium Radioisotopes
0
Membrane Glycoproteins
0
Organometallic Compounds
0
gallium 68 PSMA-11
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-382Références
Bhutiani N, Egger ME, Doughtie CA, et al. Intrapancreatic accessory spleen (IPAS): a single-institution experience and review of the literature. Am J Surg. 2017;213:816–820.
Li BQ, Xu XQ, Guo JC. Intrapancreatic accessory spleen: a diagnostic dilemma. HPB (Oxford). 2018;20:1004–1011.
Santos MPD, Rezende AP, Santos PVDF, et al. Intrapancreatic accessory spleen. Einstein (Sao Paulo). 2017;15:366–368.
Collarino A, del Ciello A, Perotti G, et al. Intrapancreatic accessory spleen detected by 68Ga DOTANOC PET/CT and 99mTc-colloid SPECT/CT scintigraphy. Clin Nucl Med. 2015;40:415–418.
Engler CC, Lemke J, Kornmann M, et al. Ectopic spleen and liver hemangioma mimicking metastatic pancreatic neuroendocrine tumor. Int J Surg Case Rep. 2015;17:139–142.
Vamadevan S, Shetty D, Le K, et al. Prostate-specific membrane antigen (PSMA) avid pancreatic neuroendocrine tumor. Clin Nucl Med. 2016;41:804–806.
Merkle EM, Boaz T, Kolokythas O, et al. Metastases to the pancreas. Br J Radiol. 1998;71:1208–1214.
Glinka J, Sanchez Claria R, Ardiles V, et al. The pancreas as a target of metastasis from renal cell carcinoma: results of surgical treatment in a single institution. Ann Hepatobiliary Pancreat Surg. 2019;23:240–244.
Minni F, Casadei R, Perenze B, et al. Pancreatic metastases: observations of three cases and review of the literature. Pancreatology. 2004;4:509–520.
Jacob J, Chargari C, Bauduceau O, et al. Pancreatic metastasis from prostate cancer. Case Rep Med. 2010;2010:826273.
Volmar KE, Jones CK, Xie HB. Metastases in the pancreas from nonhematologic neoplasms: report of 20 cases evaluated by fine-needle aspiration. Diagn Cytopathol. 2004;31:216–220.
Epstein JI, Amin MB, Beltran H, et al. Proposed morphologic classification of prostate cancer with neuroendocrine differentiation. Am J Surg Pathol. 2014;38:756–767.
Chen S, Cheung SK, Wong KN, et al. 68Ga-DOTATOC and 68Ga-PSMA PET/CT unmasked a case of prostate cancer with neuroendocrine differentiation. Clin Nucl Med. 2016;41:959–960.
Sheikhbahaei S, Werner RA, Solnes LB, et al. Prostate-specific membrane antigen (PSMA)–targeted PET imaging of prostate cancer: an update on important pitfalls. Semin Nucl Med. 2019;49:255–270.
Backhaus P, Noto B, Avramovic N, et al. Targeting PSMA by radioligands in non–prostate disease—current status and future perspectives. Eur J Nucl Med Mol Imaging. 2018;45:860–877.
Shetty D, Patel D, Le K, et al. Pitfalls in gallium-68 PSMA PET/CT interpretation—a pictorial review. Tomography. 2018;4:182–193.