Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru.
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
06
11
2019
accepted:
18
02
2020
revised:
19
03
2020
pubmed:
10
3
2020
medline:
13
5
2020
entrez:
10
3
2020
Statut:
epublish
Résumé
Anthropogenic environmental alterations such as urbanization can threaten native populations as well as create novel environments that allow human pests and pathogens to thrive. As the number and size of urban environments increase globally, it is more important than ever to understand the dispersal dynamics of hosts, vectors and pathogens of zoonotic disease systems. For example, a protozoan parasite and the causative agent of Chagas disease in humans, Trypanosoma cruzi, recently colonized and spread through the city of Arequipa, Peru. We used population genomic and phylogenomic tools to analyze whole genomes of 123 T. cruzi isolates derived from vectors and non-human mammals throughout Arequipa to determine patterns of T. cruzi dispersal. The data show significant population genetic structure within city blocks-parasites in the same block tend to be very closely related-but no population structure among blocks within districts-parasites in neighboring blocks are no more closely related to one another than to parasites in distant districts. These data suggest that T. cruzi dispersal within a block occurs regularly and that occasional long-range dispersal events allow the establishment of new T. cruzi populations in distant blocks. Movement of domestic animals may be the primary mechanism of inter-block and inter-district T. cruzi dispersal.
Identifiants
pubmed: 32150562
doi: 10.1371/journal.pntd.0007910
pii: PNTD-D-19-01885
pmc: PMC7082062
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0007910Subventions
Organisme : NIAID NIH HHS
ID : R01 AI097137
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000046
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007532
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101229
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI142572
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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