The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats.

Animals Cytokines / genetics Gene Expression Inflammation Mediators / metabolism Intestinal Diseases / etiology Intestine, Small / metabolism Male Methotrexate / administration & dosage Models, Animal Nitric Oxide / adverse effects RNA, Messenger / metabolism Rats, Wistar
Chemotherapy-induced mucositis Inflammation Methotrexate Nitric oxide

Journal

Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001

Informations de publication

Date de publication:
May 2020
Historique:
received: 05 11 2019
revised: 20 01 2020
accepted: 10 02 2020
pubmed: 11 3 2020
medline: 10 9 2020
entrez: 11 3 2020
Statut: ppublish

Résumé

The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as a consecutive administration (12.5 mg/kg/day) for 4 days. N

Identifiants

DOI: 10.1016/j.jphs.2020.02.006 PMID: 32151540
pubmed: 32151540
pii: S1347-8613(20)30018-9
doi: 10.1016/j.jphs.2020.02.006
pii:
doi:

Substances chimiques

Cytokines 0
Inflammation Mediators 0
RNA, Messenger 0
Nitric Oxide 31C4KY9ESH
Methotrexate YL5FZ2Y5U1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

30-38

Informations de copyright

Copyright © 2020 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest.

Auteurs

Saki Shiga (S)

Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.

Takuji Machida (T)

Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan. Electronic address: tmachida@hoku-iryo-u.ac.jp.

Takumi Yanada (T)

Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.

Maiko Machida (M)

Division of Pharmacotherapy, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Sapporo, Hokkaido, 006-8590, Japan.

Masahiko Hirafuji (M)

Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.

Kenji Iizuka (K)

Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The role of nitric oxide in small intestine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › The role of nitric oxide in small intestine...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › The role of nitric oxide in small intestine...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › The role of nitric oxide in small intestine...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › The role of nitric oxide in small intestine...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Intestin grêle › The role of nitric oxide in small intestine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Aminoptérine › Méthotrexate › The role of nitric oxide in small intestine...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › The role of nitric oxide in small intestine...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › The role of nitric oxide in small intestine...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › The role of nitric oxide in small intestine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › The role of nitric oxide in small intestine...