The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.

3' Untranslated Regions / genetics Binding Sites Capsid / metabolism HIV Infections / genetics HIV-1 / physiology Humans MicroRNAs / genetics Mutation Virus Integration mRNA Cleavage and Polyadenylation Factors / chemistry
3′UTR HIV RNA binding protein cleavage and polyadenylation specificity factor 6 (CPSF6) epigenetics host-pathogen interaction human immunodeficiency virus (HIV) miR-125b miRNA biogenesis microRNA (miRNA) post-transcriptional regulation

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
10 04 2020
Historique:
received: 09 08 2019
revised: 27 02 2020
pubmed: 11 3 2020
medline: 15 12 2020
entrez: 11 3 2020
Statut: ppublish

Résumé

Cleavage and polyadenylation specificity factor 6 (CPSF6) is a cellular protein involved in mRNA processing. Emerging evidence suggests that CPSF6 also plays key roles in HIV-1 infection, specifically during nuclear import and integration targeting. However, the cellular and molecular mechanisms that regulate CPSF6 expression are largely unknown. In this study, we report a post-transcriptional mechanism that regulates CPSF6 via the cellular microRNA miR-125b. An

Identifiants

DOI: 10.1074/jbc.RA119.010534 PMID: 32152226 PMC: PMC7152771
pubmed: 32152226
pii: S0021-9258(17)48600-5
doi: 10.1074/jbc.RA119.010534
pmc: PMC7152771
doi:

Substances chimiques

3' Untranslated Regions 0
MIRN125 microRNA, human 0
MicroRNAs 0
cleavage factor Im, human 0
mRNA Cleavage and Polyadenylation Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

5081-5094

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI136740
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM082251
Pays : United States
Organisme : NIDA NIH HHS
ID : R24 DA021471
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007586
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007245
Pays : United States
Organisme : NIDA NIH HHS
ID : R24 DA036420
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI122960
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007281
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI052014
Pays : United States
Organisme : NIAID NIH HHS
ID : P50 AI150481
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007593
Pays : United States

Informations de copyright

© 2020 Chaudhuri et al.

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Auteurs

Evan Chaudhuri (E)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.
Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.

Sabyasachi Dash (S)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.
Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751024, India.
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065.

Muthukumar Balasubramaniam (M)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.
Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.

Adrian Padron (A)

Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.
School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
ORCID: 0000-0002-2142-0501

Joseph Holland (J)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.
Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.

Gregory A Sowd (GA)

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.

Fernando Villalta (F)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.
Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.

Alan N Engelman (AN)

Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
ORCID: 0000-0002-9709-2591

Jui Pandhare (J)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.
Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.
School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.

Chandravanu Dash (C)

Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208 cdash@mmc.edu.
Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
ORCID: 0000-0003-4466-8355

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 3' non traduites › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Structures virales › Virion › Nucléocapside › Capside › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Intégration virale › The HIV-1 capsid-binding host factor CPSF6 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Facteurs de clivage et de polyadénylation de l'ARN messager › The HIV-1 capsid-binding host factor CPSF6 is...