Early T1 Myocardial MRI Mapping: Value in Detecting Myocardial Hyperemia in Acute Myocarditis.

Acute Disease Adult Biopsy Case-Control Studies Computed Tomography Angiography Contrast Media / administration & dosage Coronary Angiography Echocardiography Electrocardiography Female Humans Hyperemia / diagnostic imaging Magnetic Resonance Imaging / methods Male Middle Aged Myocarditis / diagnostic imaging Organometallic Compounds / administration & dosage Proof of Concept Study Sensitivity and Specificity

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
05 2020
Historique:
pubmed: 11 3 2020
medline: 28 7 2020
entrez: 11 3 2020
Statut: ppublish

Résumé

Background Hyperemia is a key component of acute myocarditis (AM). Early gadolinium uptake because of myocardial hyperemia may be quantified by using T1 mapping. Purpose To evaluate the value of early enhanced T1 shortening for the diagnosis of acute myocarditis. Materials and Methods Study participants suspected of having AM and healthy control (HC) participants were prospectively enrolled from September 2016 to May 2019. Participants underwent 1.5-T cardiac MRI including Lake Louise criteria, T2 mapping, native T1, and extracellular volume, with the addition of early enhanced T1 mapping (2 minutes after intravenous administration of 0.15 mmol/kg gadobutrol). Color-coded maps of the percentage of T1 shortening from precontrast to early postcontrast were generated. Optimal early T1 shortening cut-off value and its diagnostic performance in the identification of acute myocarditis were calculated. Results Forty-five study participants with AM (median age, 40 years; interquartile range [IQR], 20-46 years; 22 women) diagnosed according to multidisciplinary clinical evaluation, electrocardiography, laboratory test, echocardiography, cardiac MRI, and coronary CT and/or invasive angiography. Findings were confirmed by endomyocardial biopsy in 64% (29 of 45) of participants. MRI parameters were compared with 19 HC participants (median age, 39 years; IQR, 28-46 years; seven women). Median early T1 shortening was 75% (IQR, 72%-78%) in participants with AM versus 65% (IQR, 61%-66%) in HC participants (

Identifiants

DOI: 10.1148/radiol.2020191623 PMID: 32154772
pubmed: 32154772
doi: 10.1148/radiol.2020191623
doi:

Substances chimiques

Contrast Media 0
Organometallic Compounds 0
gadobutrol 1BJ477IO2L

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

316-325

Commentaires et corrections

Type : CommentIn

Auteurs

Anna Palmisano (A)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0002-1564-2060

Giulia Benedetti (G)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0001-6059-112X

Riccardo Faletti (R)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0002-8865-8637

Paola M V Rancoita (PMV)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0001-9345-691X

Marco Gatti (M)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0001-8168-5280

Giovanni Peretto (G)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0003-1815-4000

Simone Sala (S)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).

Edda Boccia (E)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0002-7433-9862

Marco Francone (M)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0002-7906-3420

Nicola Galea (N)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0003-4708-5120

Cristina Basso (C)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).

Alessandro Del Maschio (A)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0002-7004-2535

Francesco De Cobelli (F)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).

Antonio Esposito (A)

From the Experimental Imaging Centre, Radiology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy (A.P., G.B., E.B., A.D.M., F.D.C., A.E.); School of Medicine, Vita-Salute San Raffaele University, Milan, Italy (A.P., A.D.M., F.D.C., A.E.); Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, England (G.B.); Department of Surgical Sciences, Radiology Unit, University of Turin, Turin, Italy (R.F., M.G.); University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy (P.M.V.R.); Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Scientific Institute, Milan, Italy (G.P., S.S.); Department of Radiological, Oncological and Pathological Sciences, "La Sapienza" University of Rome, Rome, Italy (M.F., N.G.); and Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy (C.B.).
ORCID: 0000-0002-1170-6266

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Classifications MeSH

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