Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR.
conformational entropy
drug development
dynamics
interaction
protein function
solution NMR
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Mar 2020
06 Mar 2020
Historique:
received:
22
02
2020
revised:
01
03
2020
accepted:
04
03
2020
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
2
12
2020
Statut:
epublish
Résumé
Solution NMR spectroscopy is a unique and powerful technique that has the ability to directly connect the structural dynamics of proteins in physiological conditions to their activity and function. Here, we summarize recent studies in which solution NMR contributed to the discovery of relationships between key dynamic properties of proteins and functional mechanisms in important biological systems. The capacity of NMR to quantify the dynamics of proteins over a range of time scales and to detect lowly populated protein conformations plays a critical role in its power to unveil functional protein dynamics. This analysis of dynamics is not only important for the understanding of biological function, but also in the design of specific ligands for pharmacologically important proteins. Thus, the dynamic view of structure provided by NMR is of importance in both basic and applied biology.
Identifiants
pubmed: 32155847
pii: ijms21051829
doi: 10.3390/ijms21051829
pmc: PMC7084655
pii:
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K19415, 19K07040
Organisme : Claudia Adams Barr Program for Innovative Cancer Research
ID : ***
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