A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant.
Animals
Bacterial Proteins
/ genetics
Bacterial Toxins
/ genetics
Contact Inhibition
/ genetics
Escherichia coli
/ genetics
Escherichia coli Infections
/ microbiology
Female
Genome, Bacterial
Genomics
/ methods
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Pseudomonas Infections
/ microbiology
Pseudomonas aeruginosa
/ genetics
Signal Transduction
Virulence
Virulence Factors
/ genetics
Pseudomonas aeruginosa
comparative genomics
contact-dependent growth inhibition
virulence
whole-genome sequencing
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
24 03 2020
24 03 2020
Historique:
pubmed:
12
3
2020
medline:
8
7
2020
entrez:
12
3
2020
Statut:
ppublish
Résumé
Emerging evidence suggests the
Identifiants
pubmed: 32156726
pii: 1919198117
doi: 10.1073/pnas.1919198117
pmc: PMC7104216
doi:
Substances chimiques
Bacterial Proteins
0
Bacterial Toxins
0
Virulence Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6811-6821Subventions
Organisme : NIAID NIH HHS
ID : F32 AI108247
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135964
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI053674
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118257
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201700060C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201200026C
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129167
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI104831
Pays : United States
Commentaires et corrections
Type : ErratumIn
Type : ErratumIn
Déclaration de conflit d'intérêts
Competing interest statement: A.R.H. serves on an advisory board and as a consultant for Microbiotix, Inc. to develop type III secretion inhibitors. K.J.F.S. has a significant financial interest in Situ Biosciences, which conducts research unrelated to this work.
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